Atuação dos capsinóides sobre o perfil inflamatório e morfofisiológico do tecido hepático de ratos com obesidade induzidos por dieta hiperlipídica
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Data
2025-09-23
Autores
Simmer, Luisa Martins
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Universidade Federal do Espírito Santo
Resumo
Introduction: Among the morbidities triggered by obesity that can cause systemic damage, there is fatty liver disease associated with metabolic dysfunction (FHD), whose progression stems from the composition of lipid molecules in the liver. The growing search for natural and functional foods as an alternative to improve health highlights peppers, due to their wide use. Capsinoids, bioactive compounds present in peppers of the genus Capsicum annuum, have been trained to promote weight loss and increased caloric expenditure.Objective: To investigate the influence of capsnoid treatment on the prevention of liver disease based on inflammatory and hepatic parameters in obese rats. Methods: Wistar rats were induced, maintained, and redistributed after developing obesity induced by a high-fat diet, subjected to either the absence or presence of capsinoids treatment for 8 weeks. At the end of the 27-week experimental protocol, the animals were euthanized, and blood, plasma, adipose tissue, and liver tissue were collected for morphometric analyses. This study was approved by CEUA-UFES nº08/22. Data analysis was performed using the Kolmogorov-Smirnov normality test, and results are expressed as mean ± standard deviation. Comparisons between groups were performed using Student's t-test, and comparisons of body mass evolution and the glucose tolerance test (GTT) were performed using a two-way ANOVA in a repeated measures model, complemented by Bonferroni's multiple comparisons test. Data analysis and graphs were performed using the Graphpad Prism 8 statistical program, and the significance level was 5%. Results: The obese group (Ob), compared to the control group (C), showed higher values for body mass, caloric intake, glycemic levels, area under the glucose curve, and higher hormonal dosages of insulin, leptin, and cholesterol. However, a lower value for food intake was observed. In the capsinoid treated group (ObCap), when compared to the Ob group, no statistical differences were observed in the parameters of body mass, food intake, caloric intake, feed efficiency, adiposity index, morphometric analysis of adipose tissue, glycemic profile, and inflammatory profile. However, there was a reduction in plasma levels of ghrelin and cholesterol. Regarding the diagnosis and degree of progression of GAD, the ObCap animals showed a decrease in the amount of hepatic fat (ObCap<Ob), as well as an attenuation of GAD progression, even though this consideration was not statistically different. Conclusion: Treatment with capsinoids promoted a decrease in ghrelin, cholesterol, and hepatic fat accumulation, and also attenuated the progression of HBV in animals, which may be promising in combating chronic diseases, especially those related to lipid metabolism. However, it was not effective in promoting benefits on inflammatory parameters in the condition of obesity
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Palavras-chave
Capsinóides , Doença hepática , Obesidade , Tecido adiposo , Capsinoids , Liver disease , Obesity