Mestrado em Nutrição e Saúde
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- ItemCintura hipertrigliceridêmica e fatores associados em população rural do sudeste brasileiro(Universidade Federal do Espírito Santo, 2019-08-22) Birro, Rebeca Alvarenga Marques; Salaroli, Luciane Bresciani ; https://orcid.org/0000-0002-1881-0306; https://lattes.cnpq.br/3503255904138561; https://orcid.org/0000-0002-1650-1323; https://lattes.cnpq.br/9887525949381385; Molina, Maria del Carmen Bisi ; https://orcid.org/0000-0001-8746-5860; https://lattes.cnpq.br/9238370951122705; Paixão, Mirian Patricia Castro Pereira ; https://orcid.org/0000-0001-5537-4323; https://lattes.cnpq.br/9001805537017932abstractThe Hypertriglyceridemic Waist phenotype is a simple, low-cost clinical marker that can be applied in epidemiological settings to identify individuals at increased cardiometabolic risk, especially in populations with limited access to healthcare services. This study aimed to estimate the prevalence of the Hypertriglyceridemic Waist phenotype and to analyze associated factors among family farmers living in the rural area of Santa Maria de Jetibá, Espírito Santo, Brazil. A cross-sectional epidemiological study was conducted with 790 farmers selected through stratified sampling. Sociodemographic, occupational, lifestyle, anthropometric, and biochemical data were collected. The Hypertriglyceridemic Waist phenotype was defined according to the criteria of the International Diabetes Federation. The prevalence of the Hypertriglyceridemic Waist phenotype defined according to the International Diabetes Federation criteria was 13.03%, with higher occurrence among older individuals. In the multivariate analysis, age remained the only factor significantly associated with the outcome: 31–40 years (odds ratio = 2.48; 95 percent confidence interval: 1.17–5.17), 41–50 years (odds ratio = 3.53; 95 percent confidence interval: 1.63–7.65), and older than 50 years (odds ratio = 4.83; 95 percent confidence interval: 2.22–10.52). Sociodemographic and occupational variables did not remain associated after adjustment. These findings indicate that age-related metabolic changes and the ongoing nutritional transition also affect rural populations, even in contexts traditionally characterized by higher physical activity and agricultural labor. In conclusion, the Hypertriglyceridemic Waist phenotype represents a useful and feasible screening tool for early detection of cardiometabolic risk in rural settings, supporting surveillance actions and preventive strategies targeted at agricultural workers. Longitudinal studies are recommended to better understand causal pathways and to guide tailored public health interventions.
- ItemAlterações do estado nutricional e as percepções sobre saúde física e resultados clínicos após o bypass gástrico em Y-de-Roux: um estudo misto sequencial explanatório(Universidade Federal do Espírito Santo, 2026-02-24) Campelo, Lucas Rosas; Daboin, Blanca Elena Guerrero; https://orcid.org/0000-0001-9052-1923; https://lattes.cnpq.br/0523231791561678; Haraguchi, Fabiano Kenji; https://orcid.org/0000-0002-1019-8888; https://lattes.cnpq.br/7280084109670510; https://orcid.org/0000-0001-7224-2197; https://lattes.cnpq.br/9791801108060501; Guimarães, Michelle Ferreira; https://orcid.org/0000-0002-1707-2321; https://lattes.cnpq.br/8763513028043624; Morais, Tassiane Cristina; https://orcid.org/0000-0002-5101-2883; https://lattes.cnpq.br/1323359812956537Introduction: Obesity is a major global health challenge, and bariatric surgery stands out as an effective treatment, promoting rapid anthropometric and metabolic improvements in the first postoperative months. However, studies investigating how patients experience and interpret these initial changes in their daily lives remain scarce. Aim: To analyze the biochemical and anthropometric changes in patients undergoing bariatric surgery and to explore how these changes are experienced and perceived by these patients in terms of physical health and clinical outcomes. Materials and Methods: This is a mixed-methods study with an explanatory sequential design, conducted at a public university hospital in Espírito Santo, Brazil, integrating quantitative and qualitative methods. In the quantitative phase, anthropometric and biochemical data from 37 patients were evaluated at two time points: about two months before and six months after surgery. Data were analyzed using the paired t-test or Wilcoxon test, with a significance level of 5%. The qualitative phase involved semi-structured interviews six months after bariatric surgery with 11 patients, whose narratives were analyzed using a thematic approach and triangulated with the clinical data. Results: Quantitative results showed statistically significant reductions in body weight, BMI, total cholesterol, LDL-c, triglycerides, and glucose (p<0.05). Qualitative findings indicated significant gains in quality of life, reduction of pain, and improved mobility, but also highlighted challenges related to dietary adaptation, side effects, and the importance of family and professional support during the postoperative period. Conclusion: Bariatric surgery led to significant clinical and biochemical improvements, associated with better perceived health, functional gains, reduced medication use, improved quality of life, and greater autonomy. Additionally, qualitative findings highlighted the influence of social factors on the postoperative experience, emphasizing the need for future investigations.
- ItemAtuação dos capsinóides sobre o perfil inflamatório e morfofisiológico do tecido hepático de ratos com obesidade induzidos por dieta hiperlipídica(Universidade Federal do Espírito Santo, 2025-09-23) Simmer, Luisa Martins; Leopoldo, André Soares ; https://orcid.org/0000-0001-5999-2671; http://lattes.cnpq.br/5912424547697713; Leopoldo, Ana Paula Lima; https://orcid.org/0000-0002-4049-4418; http://lattes.cnpq.br/8738001726549455; https://orcid.org/0000-0002-0241-4253; http://lattes.cnpq.br/1504358574701495; Lopes, Andressa Bolsoni; https://orcid.org/0000-0003-1244-5667; http://lattes.cnpq.br/0097480808041638; Campos, Dijon Henrique Salomé de; https://orcid.org/0000-0002-4933-0604; http://lattes.cnpq.br/4940228608089976Introduction: Among the morbidities triggered by obesity that can cause systemic damage, there is fatty liver disease associated with metabolic dysfunction (FHD), whose progression stems from the composition of lipid molecules in the liver. The growing search for natural and functional foods as an alternative to improve health highlights peppers, due to their wide use. Capsinoids, bioactive compounds present in peppers of the genus Capsicum annuum, have been trained to promote weight loss and increased caloric expenditure.Objective: To investigate the influence of capsnoid treatment on the prevention of liver disease based on inflammatory and hepatic parameters in obese rats. Methods: Wistar rats were induced, maintained, and redistributed after developing obesity induced by a high-fat diet, subjected to either the absence or presence of capsinoids treatment for 8 weeks. At the end of the 27-week experimental protocol, the animals were euthanized, and blood, plasma, adipose tissue, and liver tissue were collected for morphometric analyses. This study was approved by CEUA-UFES nº08/22. Data analysis was performed using the Kolmogorov-Smirnov normality test, and results are expressed as mean ± standard deviation. Comparisons between groups were performed using Student's t-test, and comparisons of body mass evolution and the glucose tolerance test (GTT) were performed using a two-way ANOVA in a repeated measures model, complemented by Bonferroni's multiple comparisons test. Data analysis and graphs were performed using the Graphpad Prism 8 statistical program, and the significance level was 5%. Results: The obese group (Ob), compared to the control group (C), showed higher values for body mass, caloric intake, glycemic levels, area under the glucose curve, and higher hormonal dosages of insulin, leptin, and cholesterol. However, a lower value for food intake was observed. In the capsinoid treated group (ObCap), when compared to the Ob group, no statistical differences were observed in the parameters of body mass, food intake, caloric intake, feed efficiency, adiposity index, morphometric analysis of adipose tissue, glycemic profile, and inflammatory profile. However, there was a reduction in plasma levels of ghrelin and cholesterol. Regarding the diagnosis and degree of progression of GAD, the ObCap animals showed a decrease in the amount of hepatic fat (ObCap
- ItemEfeito dos capsinóides e do exercício físico na modulação do perfil inflamatório e tecido hepático na condição de obesidade(Universidade Federal do Espírito Santo, 2025-12-16) Nunes, Fabiane Merigueti; Leopoldo, André Soares; https://orcid.org/0000-0001-5999-2671; http://lattes.cnpq.br/5912424547697713; Leopoldo, Ana Paula Lima; https://orcid.org/0000-0002-4049-4418; http://lattes.cnpq.br/8738001726549455; https://orcid.org/0009-0003-2045-3584; http://lattes.cnpq.br/6786521209492281; Bocalini, Danilo Sales; https://orcid.org/0000-0003-3993-8277; http://lattes.cnpq.br/6290090639004596; Evangelista, Fabiana de Sant’Anna; https://orcid.org/0000-0002-8103-6923; http://lattes.cnpq.br/8871159227482154Introduction: Obesity is associated with a chronic low-grade inflammatory state, which results in metabolic changes and promotes the development of Metabolic Steatotic Liver Disease (MSLD). Physical exercise and natural compounds, such as capsinoids, stand out for presenting benefits in energy expenditure, aiding in the loss of body mass and adiposity, in addition, they suggest influencing the deposition of hepatic fat. Therefore, the objective of this study is to analyze the effects of capsinoid supplementation, combined or not with physical exercise, on the inflammatory profile and liver tissue of rats with obesity induced by a high-fat diet. Methods: Wistar rats were randomly separated into two distinct groups according to the diet offered (DP/C = standard/control diet or DH/Ob = high-fat/obese diet) to characterize obesity for 19 weeks. After this period, the Ob group was randomized regarding the absence or presence of treatment with capsinoids (10 mg/kg/day) and/or aerobic physical exercise for 8 weeks, being divided into Obese (Ob), Obese Capsinoids (ObCap), Obese Trained (ObTr) and Obese Capsinoids Trained (ObCapTr). Body composition and metabolic comorbidities were assessed using glycemic, hormonal, and inflammatory parameters. Liver disease characterization and progression were evaluated. This study was approved by CEUA-UFES nº08/22. Data normality was assessed using the Kolmogorov–Smirnov test. Results were expressed as mean ± standard deviation, and comparisons were performed using Student's t-test or two-way ANOVA with repeated measures, followed by Tukey or Bonferroni post-hoc tests, adopting 5%. Results: Final body mass, fat deposits, and total body fat were higher in the Ob group (Ob>C), confirming the obesity induction protocol. In the obese groups undergoing treatment, no effects on body composition were observed. Insulin, leptin, IL-10, and adiponectin levels remained similar across groups. In contrast, ghrelin was reduced in all treated groups (ObCap, ObTr and ObCapTr). VO2max increased significantly in the ObCapTr group. The interventions were able to attenuate hepatic fat deposition in all treatment groups (ObCap, ObTr and ObCapTr). Conclusion: Although the interventions evaluated did not promote significant changes in body composition or inflammatory parameters in obese individuals, with the exception of a reduction in ghrelin levels, the combination of capsinoid treatment and physical exercise was effective in improving aerobic capacity, as evidenced by an increase in VO₂max. Significantly, all therapeutic approaches were able to attenuate hepatic fat accumulation, preventing the progression of MSLD, although with no additional effect from the combination of treatments. These findings reinforce the interventions as promising strategies for managing MSLD caused by obesity.
- ItemFatores associados ao risco para transtornos alimentares e alimentação emocional na população adulta com TDAH(Universidade Federal do Espírito Santo, 2025-04-29) Silva, Gabriela Grillo da; Soares, Fabíola Lacerda Pires; https://orcid.org/; http://lattes.cnpq.br/; https://orcid.org/; http://lattes.cnpq.br/; Rocha, Liane Murari; https://orcid.org/; http://lattes.cnpq.br/; Viana, Mirelle Lomar; https://orcid.org/; http://lattes.cnpq.br/; Lucas, Maria Salete Junqueira; https://orcid.org/; http://lattes.cnpq.br/; Cabrini, Danielle; m; mIntroduction: The characteristics of Attention Deficit Hyperactivity Disorder (ADHD) may contribute to the development of eating disorders (EDs) in this population, in addition to their frequent engagement in emotional eating. Objective: To assess the risk of EDs and emotional eating, as well as their associated factors, in the adult population with ADHD residing in the Metropolitan Region of Greater Vitória (RMGV). Method: The study included individuals aged 18 to 59 years with a medical diagnosis of ADHD. Data were collected through an online questionnaire using self-administered instruments, which included sociodemographic, clinical, lifestyle, nutritional status, and self-compassion score assessments. ED risk was evaluated using the Eating Disorders Examination Questionnaire (EDE-Q), while emotional eating was assessed using the "Emotional Eating" subscale of the Three-Factor Eating Questionnaire – reduced 21-item version (TFEQ-R21). Data analysis was performed using JASP software, version 18.3. Results: A total of 151 individuals participated in the study, 68.7% of whom were female. The median age was 25 years, and most participants did not live with a partner. The median and interquartile range of the EDE-Q score assessing ED risk was 2.32 (2.41). Regarding the emotional eating score, the value was 50.00 (44.44). Each 1-point increase in BMI was associated with a 0.053-point increase in ED risk (p = 0.005). Conversely, each 1-point increase in the self-compassion score was associated with a 0.339-point decrease in the EDE-Q score (p = 0.009). Engaging in dieting practices was also linked to an increased risk of EDs. Mediation analysis revealed that emotional eating mediates the relationship between these variables and ED risk. When analyzing the factors associated with emotional eating as an outcome, higher BMI, dieting practices, marital status, and the presence of comorbidities were found to be predictors of increased emotional eating in this population. Conclusion: Higher BMI and dieting practices are associated with increased ED risk, whereas self compassion appears to be a protective factor. Emotional eating mediates the relationship between these variables and ED risk. Additionally, higher BMI, dieting practices, marital status, and the presence of comorbidities are predictors of increased emotional eating in this population.