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Documentos Administrativos Documentos administrativos da UFES (Relatórios institucionais, Atos normativos, Resoluções, Portarias e etc)Livros Digitais Livros digitais "ebooks" (e-livros) publicados ou adquiridos pela UFESProdução Científica Produção científica e técnica da UFES, como Artigos, livros e capítulos, trabalhos apresentados em eventos, entrevistas, resenhas, traduções, patentes, cultivares, marcas, etc.Teses e Dissertações Teses e dissertações depositadas no repositório da UFESTrabalhos Acadêmicos Trabalhos acadêmicos de conclusão de curso (TCC) de graduação e pós-graduação lato sensu
Submissões Recentes
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Synthesis and biological evaluation of cytotoxic paeonol derivatives, aryne-functionalized naphthoquinones with trypanocidal activity, and BODIPY-based fluorophores
(Universidade Federal do Espírito Santo, 2025-12-11) Figueroa, Laura Patricia Rocha; Silva Junior, Eufrânio Nunes da; https://orcid.org/0000-0003-1281-5453; https://lattes.cnpq.br/5627593695811199; Borges, Warley de Souza; https://orcid.org/0000-0003-4475-1028; https://lattes.cnpq.br/9742402285970429; https://orcid.org/0000-0003-2654-8800; https://lattes.cnpq.br/7977430230308850; Nascimento, Vanessa; https://orcid.org/0000-0001-9413-7638; https://lattes.cnpq.br/9472579719230658; Thomas, Juliana Christina; https://orcid.org/0000-0003-2070-8623; https://lattes.cnpq.br/5141387978902606; Miranda, Amanda Silva de; https://lattes.cnpq.br/6194642305921194; Cunha Neto, Álvaro; https://orcid.org/0000-0002-1814-6214; https://lattes.cnpq.br/7448379486432052; Regasini, Luis Octavio; https://orcid.org/0000-0001-8574-0670; https://lattes.cnpq.br/0992736452764550
This work presents three projects related to the organic synthesis of natural product derivatives and bioluminescent moieties with different applications. The first project focused on Paeonol-related compounds and their biological potential through the synthesis of Paeonol-derived ethers and benzofurans via bimolecular nucleophilic substitution reactions. A total of four ether derivatives and seven benzofuran derivatives were obtained. The cytotoxic activity of all synthesized compounds was evaluated, and three compounds were active against the HCT116 cell line, showing over 60% growth inhibition. Notably, compound 44e exhibited a strong IC50 value of 0.2 μM, supporting its potential as an anticancer agent. The second study explored the regioselective synthesis of functionalized 1,4-naphthoquinones via aryne chemistry, through the generation and trapping of naphthoquinonynes. Twelve amine derivatives and six pyridine N-oxide derivatives were obtained, providing access to A-ring-functionalized naphthoquinones, including nine new compounds. Their trypanocidal activity was evaluated, and fourteen naphthoquinones showed higher activity than benznidazole, the current drug used for Chagas disease. Two compounds were approximately ten times more potent. These results highlight the value of this approach for the discovery of new trypanocidal agents and demonstrate the efficiency and versatility of the methodology. The third chapter showed the design and synthesis of BODIPY-based fluorescent molecules. A series of krypto-BODIPY and meso-phenyl-BODIPY derivatives was synthesized, including eight new compounds such as mono- and di-halogenated scaffolds, acetylated analogues, Sonogashira coupling products, and a symmetric bis-BODIPY alkyne. The results demonstrate that both kryptopyrrole and meso-phenyl frameworks tolerate electrophilic substitution, C–H activation, and Pd-catalyzed cross-coupling reactions, enabling efficient diversification of BODIPY fluorophores. Overall, this work demonstrates the development of efficient synthetic strategies for biologically relevant and fluorescent molecular scaffolds, contributing new compounds and methodologies with potential applications in medicinal chemistry and chemical biology.
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Por uma educação pluriepistêmica : literatura indígena na formação de educadoras(es) na perspectiva decolonial
(Universidade Federal do Espírito Santo, 2026-02-10) Cerri, Thelma Chiarelli; Miranda, Marina Rodrigues ; https://orcid.org/0000-0002-1133-7827; https://lattes.cnpq.br/4087302830515226; https://orcid.org/0009-0002-9267-1073; https://lattes.cnpq.br/3064425025596625; Locatelli, Andrea Brandão ; https://orcid.org/0000-0001-7305-0787; https://lattes.cnpq.br/8754516218846670; Macedo, Roberto Sidnei Alves ; https://orcid.org/0000-0002-5350-5999; https://lattes.cnpq.br/4548303459275924
This study aimed to conduct research in Basic Education, using Literary Circles of Indigenous authors as formative devices grounded in their epistemologies and cosmologies, contributing to the transformation of educational processes toward the emergence of decolonial knowledge. The research examined the influence of colonial thought on the ideological framework of educators at the Francisco José Mattedi Municipal School of Integral Rural Education, as well as possible multi-epistemic pedagogical connections. Dialogues were established with the teaching staff in order to engage with theoretical perspectives rooted in decolonial cultural studies. The study draws on the contributions of Anibal Quijano (2005), Catherine Walsh (2018), Walter Mignolo (2003), and Paulo Freire (2022), among others, whose work supports the deconstruction of colonizing practices rooted in hegemonic Eurocentric thought. Methodologically, the research adopted a qualitative approach, developed through an ethnographic study based on participant observation of pedagogical practices at the school. As a research instrument, dialogical cycles were organized as a field of study involving both teachers and students from the school community. This methodological framework incorporated the political principles of Indigenous affirmation established by Brazilian Law No. 11.645/2008, which mandates the teaching of Indigenous History and Culture in Brazilian education. The dialogical processes were grounded in situated theoretical perspectives and enriched by Indigenous authors such as Smith (2021), Dorrico (2018), Graúna (2013), Krenak (2022), as well as the literary circularity proposed by Yamã (2012) and Miranda (2012, 2021, 2022, 2023, 2024). These engagements fostered alternative imaginaries of Indigenous knowledge production and cultivated, among students and educators, a critical awareness informed by decolonization and the de-standardization of a still rigid Basic Education curriculum. The study advocates for a curricular framework aligned with cultural specificities and constructed through dialogue with the school community, articulating ancestral knowledge with contemporary knowledge, and integrating principles of Popular Rural Education and Indigenous Education in order to promote collective well-being
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Taxa real de câmbio e diferencial de produtividade : testes do efeito Balassa-Samuelson para a economia brasileira
(Universidade Federal do Espírito Santo, 2026-02-20) Cordeiro, Felipe Eduardo Megale; Moreira, Ricardo Ramalhete ; https://orcid.org/0000-0002-1905-4872; https://lattes.cnpq.br/3263921271806291; https://orcid.org/0009-0005-4698-381X; https://lattes.cnpq.br/2543417261882155; Sessa, Celso Bissoli ; https://orcid.org/0000-0001-7616-0244; https://lattes.cnpq.br/2412019938676749; Gala, Paulo Sérgio de Oliveira Simões ; https://orcid.org/0000-0002-1972-1188; https://lattes.cnpq.br/7346817451274861
This article investigates the empirical validity of the Balassa-Samuelson (BS) effect in the Brazilian economy over the period 2003–2023. Employing the BEER framework, as proposed by Clark and MacDonald (1998), and Autoregressive Distributed Lag (ARDL) models with the Bound Test, following Pesaran et al. (2001), the study examines the long-run relationship between the real exchange rate (RER) and productivity differentials using alternative proxies. The results provide evidence consistent with the BS effect, albeit sensitive to the measurement employed. The proxy based on Total Factor Productivity (BSPTF) yields coefficients in line with the theoretical hypothesis—according to which productivity gains in the more productive economy (USA) relative to the less productive economy (Brazil) lead to a real depreciation of the brazilian exchange rate—whereas the labor productivity proxies (BSPROD and BSREPR) display signs inconsistent with the theory, in line with recent findings in the international literature (GUBLER; SAX, 2014, 2019). Furthermore, the findings indicate the predominance of financial factors, such as global risk (VIX) and the international investment position (IIP), over real fundamentals in determining the RER. It is concluded that, during the period under analysis, the risk premium exerted a stronger influence than productivity differentials, suggesting a high sensitivity of Brazil’s exchange rate dynamics to external volatility and institutional fragilities
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Influência da distribuição geográfica e dos aspectos fenológicos de Tithonia diversifolia Hemsl. A. Gray (Asteraceae) na sua composição química e atividade biológica
(Universidade Federal do Espírito Santo, 2026-02-12) Zatta, Ana Carolini Cavallieri; Batitucci, Maria do Carmo Pimentel ; https://orcid.org/0000-0002-3485-4448; https://lattes.cnpq.br/0010148251489155; https://orcid.org/0000-0001-5668-0680; https://lattes.cnpq.br/8402221702437851; França, Hildegardo Seibert ; https://orcid.org/0000-0001-6129-8793; https://lattes.cnpq.br/1284874997224988; Souza, Iara da Costa ; https://orcid.org/0000-0003-2726-3313; https://lattes.cnpq.br/5391583114634391
Tithonia diversifolia Hemsl. A. Gray, popularly known as Mexican sunflower, is a species of the Asteraceae family with recognized pharmacological potential, including antioxidant, anti-inflammatory, and antiproliferative activities. The variability of the chemical composition of plant species can be influenced by environmental and phenological factors, directly impacting their bioactivity. This study aimed to analyze and correlate the chemical composition and antiproliferative activity of hydroalcoholic leaf extracts of Tithonia diversifolia from five locations in Espírito Santo (Colatina, Muniz Freire, Viana, UFES Vitória, and Santa Teresa), collected at vegetative (2014) and reproductive (2015) stages. Furthermore, to assess temporal stability, a new collection was performed after 10 years (2024) at the UFES and Santa Teresa locations. Chemical characterization of the extracts was performed using Fourier Transform Infrared Spectroscopy (FTIR), high-resolution Electrospray Ionization Mass Spectrometry (ESI-TOF), and chemometric analyses (Principal Component Analysis - PCA and Hierarchical Cluster Analysis - HCA). The results revealed a diversified chemical profile, with the annotation of secondary metabolites of interest, such as hydroxycinnamic acids (e.g., caffeoylquinic acid), flavonoids (e.g., apigenin, naringenin), sesquiterpene lactones (e.g., tagitinin A), and fatty acids. Multivariate analysis revealed a clustering of samples based on geographical origin, with samples from Santa Teresa standing out for presenting a distinct chemical profile and greater temporal variability. Biological activity was evaluated through in vitro assays using the MCF-7 (breast carcinoma) and MCF-10A (non-tumor mammary epithelium) cell lines. Cell viability assays (MTT) demonstrated that the extracts have concentration-dependent antiproliferative activity against MCF-7 cells. The MUF4 and MUF5 extracts, from Muniz Freire, showed the highest Selectivity Indices (SI > 2.0), indicating preferential action against tumor cells. Meanwhile, the proliferation assay (crystal violet) and clonogenicity assays corroborated the inhibition of growth and colony-forming capacity of MCF-7 cells treated with these extracts. Investigation of the mechanisms of action revealed that MUF4 and MUF5 induced a significant increase in the production of reactive oxygen species (ROS), caused cell cycle arrest, predominantly in the S and G2/M phases, and activated apoptosis, as confirmed by the Annexin V/PI assay. However, no significant induction of histone H2AX phosphorylation (γ-H2AX), a marker of double-strand DNA breaks, was observed, suggesting that cytotoxicity is not mediated by direct genotoxicity, but rather by redox imbalance and cellular stress. It is concluded that the chemical composition and antiproliferative activity of Tithonia diversifolia vary according to the geographical location and phenological stage of the plant. The extracts from Muniz Freire stood out for their selective and potent activity against breast cancer cells, acting through the induction of oxidative stress, disruption of the cell cycle, and activation of apoptosis. The results reinforce the therapeutic potential of the species and highlight the importance of considering botanical origin and growing conditions in the development of phytomedicines
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Infâmias resistências : mulheres-pesquisadoras-infames traçando caminhos de pesquisa-vida
(Edufes, 2026) Siqueira, Luziane de Assis Ruela (org.); Costa, Janaina da Silva (org.); Bernabé, Marina Francisqueto (org.); Cordeiro, Sabrina Ribeiro (org.)
Infâmias resistências: mulheres-pesquisadoras infames traçando caminhos de pesquisa-vida reúne textos produzidos no âmbito do Grupo de Pesquisa Infâmias Resistências, vinculado ao Programa de Pós-Graduação em Psicologia Institucional da Universidade Federal do Espírito Santo. A obra nasce do encontro entre pesquisa e experiência, propondo uma ciência atravessada pela vida, pela escuta e pelas narrativas de mulheres que desafiam silenciamentos históricos. Inspirado na reflexão de Michel Foucault sobre as “vidas infames”, o livro aposta na potência de dar visibilidade a existências frequentemente marginalizadas, especialmente as de mulheres cujas histórias são marcadas por desigualdades, violências e processos de resistência. A partir de diferentes caminhos metodológicos — como narrativas, escrevivências, cartografias, cartas e fotoescrevivências — os capítulos abordam temas como maternidade, sexualidade, racismo, violência de gênero, cuidado, militância e práticas feministas na academia e na vida cotidiana. Mais do que um conjunto de pesquisas, a obra se apresenta como um tecido coletivo de experiências e reflexões que afirmam outras formas de produzir conhecimento. Ao entrelaçar teoria e vida, as autoras reivindicam uma escrita comprometida com a transformação social e com a construção de uma academia mais plural, sensível e politicamente engajada