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Documentos Administrativos Documentos administrativos da UFES (Relatórios institucionais, Atos normativos, Resoluções, Portarias e etc)Livros Digitais Livros digitais "ebooks" (e-livros) publicados ou adquiridos pela UFESProdução Científica Produção científica e técnica da UFES, como Artigos, livros e capítulos, trabalhos apresentados em eventos, entrevistas, resenhas, traduções, patentes, cultivares, marcas, etc.Teses e Dissertações Teses e dissertações depositadas no repositório da UFESTrabalhos Acadêmicos Trabalhos acadêmicos de conclusão de curso (TCC) de graduação e pós-graduação lato sensu
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Ata da 1ª reunião ordinária da Câmara de Pesquisa - 23/02/2026
(Universidade Federal do Espírito Santo, 2026-02-23) Pró-Reitoria de Pesquisa e Pós-Graduação
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“A caminho da civilização”: viajantes e povos indígenas no Brasil do século XIX
(Universidade Federal do Espírito Santo, 2025-08-29) Vieira, Izadora de Souza; Silva, Sandro José da; https://orcid.org/0000-0002-4124-9430; http://lattes.cnpq.br/9873497099288005; https://orcid.org/0009-0007-7138-6683; http://lattes.cnpq.br/9602097091066713; Pavesi, Patrícia Pereira; https://orcid.org/0000-0002-8435-7239; http://lattes.cnpq.br/3952116395952727; Silva, Geovana Tabachi; https://orcid.org/0000-0002-2047-775X; http://lattes.cnpq.br/6748143521713365
This work describes the production of knowledge about Indigenous peoples in Brazil from the perspective of naturalist travelers. This dissertation explores the experience of Botocudo Kuêk, or Joachim Quack (1804-1834), and the work of the naturalist traveler Maximiliano zu Wied Neuwied (1782-1867). The object of analysis that supports the dissertation is the travelers' imaginative work on Indigenous societies, more specifically, colonial societies, understood as a perspective that oscillates between domination and protection, with the kidnapping of Indigenous children as the turning point. The return to "ethnobiography" (REVEL, 1998:22) is inserted into discussions on power struggles and interdependence, with the connecting thread between the colonial context and the production of tutelary politics, which guides the analysis of the Indigenous place in the production of knowledge, the construction of otherness, and the activation of agencies. Through a bibliographical review, I seek to describe how otherness appears in the works of naturalist travelers and helps us find the constitution of knowledge about the founding of the nation.
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Entre signos, significações e saberes: o multiletramento na formação continuada de professores do município de Alegre/ES
(Universidade Federal do Espírito Santo, 2025-12-19) Pirovani, Fernanda de Freitas Machado; Meira, Ana Cláudia Hebling; https://orcid.org/0000-0001-8848-6903; http://lattes.cnpq.br/7971806472494167; Bortoleto, Edivaldo José; https://orcid.org/0000-0002-7748-8361; http://lattes.cnpq.br/4348928198416364; https://orcid.org/0009-0004-5487-5491; http://lattes.cnpq.br/0170160663577269; Anastácio, Simone Aparecida Fernandes; https://orcid.org/0000-0002-7030-6748; http://lattes.cnpq.br/0532528200582514; Vitorino, Artur José Renda; https://orcid.org/0000-0002-8654-3182; http://lattes.cnpq.br/3811004108670430
This dissertation aimed to understand teacher education in the context of Portuguese Language (PL) teaching, mediated by multiliteracies, based on teachers’ perceptions, analyzing how these approaches may foster the learning of students in the 5th year of Elementary Education (EE). The study contributes to the debate on Portuguese Language teaching by grounding itself, initially, in the perspective of multiliteracies, as proposed by Rojo (2012), and subsequently in the Semiotics of Charles Sanders Peirce (2005), understanding language as a system of signs constituted within social relations and historical and cultural contexts. A methodological approach oriented toward the development of basic proficiencies in reading, writing, and multiliteracies was adopted, articulating these competencies with a curriculum that prioritizes integrated practices, such as reading, linguistic analysis, literary analysis, text production, critical reflection, interpretation, and grammar. To this end, the research was conducted in a municipal public school in Alegre, Espírito Santo, through a qualitative and exploratory approach. Semi-structured interviews were carried out with teachers working in the 5th year, with the aim of analyzing the possible contributions of Peircean semiotics to the notion of multiliteracies, considering the learning gaps observed among students in the final years of Elementary Education with regard to reading, text interpretation, and writing. It is important to emphasize that issues related to reading, text interpretation, and writing are not limited to curricular prescriptions or pedagogical practices, but are articulated with broader socio-historical-economic contexts, permeated by neoliberal logic that impacts students in public schools, who are predominantly from working-class backgrounds and socially subalternized groups. In this scenario, the research sought to demonstrate that Portuguese Language teaching can transcend normative and instrumental memorization, constituting itself as a space for the construction of signs, meanings, knowledge, and dialogue, especially when guided by a semiotic perspective.
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Ovarian cancer chemoresistance: the role of inflammasomes in cisplatin resistance and the impact of mitochondrial reprogramming in parp inhibitor resistance
(Universidade Federal do Espírito Santo, 2025-12-17) Souza, Josiany Carlos de; Rangel, Leticia Batista Azevedo; https://orcid.org/0000-0002-6150-4064; http://lattes.cnpq.br/6706127386696883; https://orcid.org/0000-0001-6777-0227; http://lattes.cnpq.br/1856469122580933; Silva, Adriana Madeira Alvares da; https://orcid.org/0000-0002-8078-0304; http://lattes.cnpq.br/6445492335035108; Paula, Flavia de; https://orcid.org/0000-0001-8679-2982; http://lattes.cnpq.br/7913201450663683; Tessarollo, Nayara Gusmão; http://lattes.cnpq.br/8607496356516938; Lyra Junior, Paulo Cilas Morais; https://orcid.org/0000-0002-4403-6684; http://lattes.cnpq.br/5084773867229309
Epithelial ovarian cancer (EOC) is the most lethal gynecological neoplasm, characterized by high recurrence rates and resistance to cisplatin (CDDP) and PARP inhibitor treatments. Understanding the mechanisms related to these phenotypes is urgent. Therefore, in the first chapter of this study, the role of NLRP1 and NLRP3 inflammasomes and pyroptosis in CDDP chemoresistance is investigated. Cell viability of A2780, ACRP, and OVCAR3 cell lines were measured by the MTT assay, and IC50 values were determined. Cytokine levels in the supernatant were measured by ELISA. Caspase-1 activation was detected by the Caspase-Glo® 1 assay. The cell death profile was determined by flow cytometry (Annexin V/PI), and membrane pore formation was measured using PI. A cell migration assay was performed combining CDDP and the caspase-1 inhibitor. The IC50 of primary cells (PtAF) and viability after treatment with NLRP3 inhibitor (MCC950)+CDDP were determined by Cell Counting Kit-8 (CCK-8). The IC50 values indicated different CDDP resistance profiles in the cell lines. Secretion of inflammatory cytokines, caspase-1 activation, lytic cell death profile, and pore formation were higher in cells treated with CDDP. Caspase-1+CDDP inhibition reduced cell migration. PtAF treated with MCCC950+CDDP decreased cell viability and proliferation. The data suggest that inflammasome activation and pyroptosis are mechanisms associated with EOC chemoresistance to CDDP, contributing to the devastating scenario of this disease. Targeting these pathways may represent a promising treatment strategy. In the second chapter, the effect of the PARP inhibitor (Rucaparib) on mitochondrial reprogramming and its contribution to resistance is explored. Using primary cells: PtAF, PtD, and PtAD, viability assays with Rucaparib and Fludarabine Phosphate were performed by CCK-8. Oxygen consumption and extracellular acidification were detected by Seahorse. Mitochondrial content and mitochondrial membrane potential were determined by immunofluorescence with Mitotracker deepened and TMRE. NADH content was identified by autofluorescence microscopy (FLIM). The viability of cells treated with mitochondrial complex inhibitors was determined by crystal violet. The results indicated increased mitochondrial content, oxygen consumption, extracellular acidification especially in PtAF and increased NADH levels in the other cell lines. The combination of fludarabine phosphate with rucaparib had an additional cytotoxic effect on PtAF and PtD. These data suggest that PARPi affects mitochondrial metabolism and mass of cell lines differentially and that NAD transport (via SLC25A51) may play a key role in resistance, representing a potential target. Taken together, these data contribute to understanding the mechanisms underlying treatment resistance in EOC, highlighting inflammatory and mitochondrial targets as potential pathways for new therapeutic approaches.
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Interação entre as condições de armazenamento e o desempenho biológico do fungo Trichoderma harzianum no cultivo de Impatiens hybrida
(Universidade Federal do Espírito Santo, 2026-02-02) Ribeiro, Layra Cortes da Silva; Moulin, Monique Moreira; https://orcid.org/0000-0001-8993-4835; http://lattes.cnpq.br/8654999153826715; Bento, Cíntia dos Santos; https://orcid.org/0000-0003-1639-4166; http://lattes.cnpq.br/4236145191829946; https://orcid.org/0009-0002-9587-1994; http://lattes.cnpq.br/4184469218141889; Sudré, Cláudia Pombo; https://orcid.org/0000-0001-6743-7205; http://lattes.cnpq.br/4185732042391423; Carrijo, Tatiana Tavares ; https://orcid.org/0000-0002-8366-0738; http://lattes.cnpq.br/0479854777557016
Impatiens hybrida hort., known as SunPatiens®, is an ornamental plant of high economic relevance, notable for its heat resistance. The fungus Trichoderma spp. is widely recognized for its potential as a plant biostimulant, although its application in Impatiens hybrida remains largely unexplored. This study evaluated the efficacy of Trichoderma harzianum on the morphoagronomic growth of SunPatiens® and the expression of DGL1, NAC1, and EXP1genes related to root development, as well as its viability in storage environments under two different temperatures. The experiment was conducted with two SunPatiens® varieties in a commercial substrate inoculated with T. harzianum (strain ESALQ 1306) and stored in two distinct environments. Microbiological counts were performed biweekly, and gene expression was analyzed by RT-qPCR using the 2 Ct method. Statistical analysis was performed using ANOVA, with residual normality checks and logarithmic data transformation when necessary. Results demonstrated that although the viability of T. harzianum (strain ESALQ 1306) remained stable in both locations, its efficacy was superior in plants where the substrate was stored in a mild temperature environment, in contrast to the high thermal stress environment. The highest gene expression occurred up to 20 days after inoculation, indicating that both time and temperature influence the functional activity of the fungus. Thus, it can be concluded that T. harzianum (strain ESALQ 1306) promoted the growth of Impatiens hybrida and stimulated the expression of genes related to root development. Despite the maintenance of fungal viability in both environments, its agronomic efficacy was higher when stored in locations with temperatures below 30 °C, highlighting the importance of adequate conditions to preserve its functionality as a bioinput