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Cintura hipertrigliceridêmica e fatores associados em população rural do sudeste brasileiro
(Universidade Federal do Espírito Santo, 2019-08-22) Birro, Rebeca Alvarenga Marques; Salaroli, Luciane Bresciani ; https://orcid.org/0000-0002-1881-0306; https://lattes.cnpq.br/3503255904138561; https://orcid.org/0000-0002-1650-1323; https://lattes.cnpq.br/9887525949381385; Molina, Maria del Carmen Bisi ; https://orcid.org/0000-0001-8746-5860; https://lattes.cnpq.br/9238370951122705; Paixão, Mirian Patricia Castro Pereira ; https://orcid.org/0000-0001-5537-4323; https://lattes.cnpq.br/9001805537017932
abstractThe Hypertriglyceridemic Waist phenotype is a simple, low-cost clinical marker that can be applied in epidemiological settings to identify individuals at increased cardiometabolic risk, especially in populations with limited access to healthcare services. This study aimed to estimate the prevalence of the Hypertriglyceridemic Waist phenotype and to analyze associated factors among family farmers living in the rural area of Santa Maria de Jetibá, Espírito Santo, Brazil. A cross-sectional epidemiological study was conducted with 790 farmers selected through stratified sampling. Sociodemographic, occupational, lifestyle, anthropometric, and biochemical data were collected. The Hypertriglyceridemic Waist phenotype was defined according to the criteria of the International Diabetes Federation. The prevalence of the Hypertriglyceridemic Waist phenotype defined according to the International Diabetes Federation criteria was 13.03%, with higher occurrence among older individuals. In the multivariate analysis, age remained the only factor significantly associated with the outcome: 31–40 years (odds ratio = 2.48; 95 percent confidence interval: 1.17–5.17), 41–50 years (odds ratio = 3.53; 95 percent confidence interval: 1.63–7.65), and older than 50 years (odds ratio = 4.83; 95 percent confidence interval: 2.22–10.52). Sociodemographic and occupational variables did not remain associated after adjustment. These findings indicate that age-related metabolic changes and the ongoing nutritional transition also affect rural populations, even in contexts traditionally characterized by higher physical activity and agricultural labor. In conclusion, the Hypertriglyceridemic Waist phenotype represents a useful and feasible screening tool for early detection of cardiometabolic risk in rural settings, supporting surveillance actions and preventive strategies targeted at agricultural workers. Longitudinal studies are recommended to better understand causal pathways and to guide tailored public health interventions.
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Durabilidade de concretos com incorporação de escória de Ferroníquel como material cimentício suplementar : migração de íons cloreto, carbonatação e análise microestrutural
(Universidade Federal do Espírito Santo, 2026-02-26) Quinquim, Thiago Almeida; Sakata, Rafael Dors; https://orcid.org/0000-0002-7022-3846; https://lattes.cnpq.br/3547547454752538; Pilar, Ronaldo; https://orcid.org/0000-0002-1906-2071; https://lattes.cnpq.br/6669573444640365; https://orcid.org/0009-0000-5606-241X; https://lattes.cnpq.br/9143527494194512; Vieira, Geilma Lima; https://orcid.org/0000-0001-6148-3307; https://lattes.cnpq.br/5783172236615493; Araújo, Geórgia Serafim; https://orcid.org/0000-0002-2029-6334; https://lattes.cnpq.br/4707150428037806; Medeiros, Marcelo Henrique Farias de; https://orcid.org/0000-0003-3112-9715; https://lattes.cnpq.br/2049752365695485
Partial replacement of Portland cement with supplementary cementitious materials (SCMs) is a consistent strategy to enhance the sustainability of the construction sector by reducing the clinker factor and its environmental impacts, especially when these materials are regionally available. This study investigated the technical feasibility of incorporating ground ferronickel slag (FNS) as an SCM in concrete, evaluating mechanical performance, durability indicators, and microstructural evidence. The mixtures were produced with a constant water-to-binder ratio and different replacement levels (including a reference mixture and a composition with inert limestone filler). Performance was assessed through compressive strength, chloride transport tests (passed charge and migration coefficient), electrical resistivity, volume of permeable voids, and accelerated carbonation. The interpretation of the results was supported at the microstructural level by synchrotron X-ray diffraction with quantitative refinement and thermogravimetric analysis, enabling relationships between composition/mineralogy and hydration evolution to be established. FNS, characterized by a low Ca/Si ratio and a considerable siliceous amorphous fraction, exhibited predominantly late pozzolanic reactivity, consuming Ca(OH)2 and forming additional C–S–H, which promoted matrix densification. At later ages, a consistent reduction in ionic transport and volume of permeable voids were observed, accompanied by increased electrical resistivity, indicating greater resistance to chloride ingress. However, high replacement levels increased vulnerability to carbonation, mainly at early ages, attributed to clinker dilution and reduced alkaline reserve, although late age densification partially mitigated this effect. Overall, replacement levels around 30% provided the best balance between mechanical performance, durability gains, and carbonation resistance.
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Alterações do estado nutricional e as percepções sobre saúde física e resultados clínicos após o bypass gástrico em Y-de-Roux: um estudo misto sequencial explanatório
(Universidade Federal do Espírito Santo, 2026-02-24) Campelo, Lucas Rosas; Daboin, Blanca Elena Guerrero; https://orcid.org/0000-0001-9052-1923; https://lattes.cnpq.br/0523231791561678; Haraguchi, Fabiano Kenji; https://orcid.org/0000-0002-1019-8888; https://lattes.cnpq.br/7280084109670510; https://orcid.org/0000-0001-7224-2197; https://lattes.cnpq.br/9791801108060501; Guimarães, Michelle Ferreira; https://orcid.org/0000-0002-1707-2321; https://lattes.cnpq.br/8763513028043624; Morais, Tassiane Cristina; https://orcid.org/0000-0002-5101-2883; https://lattes.cnpq.br/1323359812956537
Introduction: Obesity is a major global health challenge, and bariatric surgery stands out as an effective treatment, promoting rapid anthropometric and metabolic improvements in the first postoperative months. However, studies investigating how patients experience and interpret these initial changes in their daily lives remain scarce. Aim: To analyze the biochemical and anthropometric changes in patients undergoing bariatric surgery and to explore how these changes are experienced and perceived by these patients in terms of physical health and clinical outcomes. Materials and Methods: This is a mixed-methods study with an explanatory sequential design, conducted at a public university hospital in Espírito Santo, Brazil, integrating quantitative and qualitative methods. In the quantitative phase, anthropometric and biochemical data from 37 patients were evaluated at two time points: about two months before and six months after surgery. Data were analyzed using the paired t-test or Wilcoxon test, with a significance level of 5%. The qualitative phase involved semi-structured interviews six months after bariatric surgery with 11 patients, whose narratives were analyzed using a thematic approach and triangulated with the clinical data. Results: Quantitative results showed statistically significant reductions in body weight, BMI, total cholesterol, LDL-c, triglycerides, and glucose (p<0.05). Qualitative findings indicated significant gains in quality of life, reduction of pain, and improved mobility, but also highlighted challenges related to dietary adaptation, side effects, and the importance of family and professional support during the postoperative period. Conclusion: Bariatric surgery led to significant clinical and biochemical improvements, associated with better perceived health, functional gains, reduced medication use, improved quality of life, and greater autonomy. Additionally, qualitative findings highlighted the influence of social factors on the postoperative experience, emphasizing the need for future investigations.
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Synthesis and biological evaluation of cytotoxic paeonol derivatives, aryne-functionalized naphthoquinones with trypanocidal activity, and BODIPY-based fluorophores
(Universidade Federal do Espírito Santo, 2025-12-11) Figueroa, Laura Patricia Rocha; Silva Junior, Eufrânio Nunes da; https://orcid.org/0000-0003-1281-5453; https://lattes.cnpq.br/5627593695811199; Borges, Warley de Souza; https://orcid.org/0000-0003-4475-1028; https://lattes.cnpq.br/9742402285970429; https://orcid.org/0000-0003-2654-8800; https://lattes.cnpq.br/7977430230308850; Nascimento, Vanessa; https://orcid.org/0000-0001-9413-7638; https://lattes.cnpq.br/9472579719230658; Thomas, Juliana Christina; https://orcid.org/0000-0003-2070-8623; https://lattes.cnpq.br/5141387978902606; Miranda, Amanda Silva de; https://lattes.cnpq.br/6194642305921194; Cunha Neto, Álvaro; https://orcid.org/0000-0002-1814-6214; https://lattes.cnpq.br/7448379486432052; Regasini, Luis Octavio; https://orcid.org/0000-0001-8574-0670; https://lattes.cnpq.br/0992736452764550
This work presents three projects related to the organic synthesis of natural product derivatives and bioluminescent moieties with different applications. The first project focused on Paeonol-related compounds and their biological potential through the synthesis of Paeonol-derived ethers and benzofurans via bimolecular nucleophilic substitution reactions. A total of four ether derivatives and seven benzofuran derivatives were obtained. The cytotoxic activity of all synthesized compounds was evaluated, and three compounds were active against the HCT116 cell line, showing over 60% growth inhibition. Notably, compound 44e exhibited a strong IC50 value of 0.2 μM, supporting its potential as an anticancer agent. The second study explored the regioselective synthesis of functionalized 1,4-naphthoquinones via aryne chemistry, through the generation and trapping of naphthoquinonynes. Twelve amine derivatives and six pyridine N-oxide derivatives were obtained, providing access to A-ring-functionalized naphthoquinones, including nine new compounds. Their trypanocidal activity was evaluated, and fourteen naphthoquinones showed higher activity than benznidazole, the current drug used for Chagas disease. Two compounds were approximately ten times more potent. These results highlight the value of this approach for the discovery of new trypanocidal agents and demonstrate the efficiency and versatility of the methodology. The third chapter showed the design and synthesis of BODIPY-based fluorescent molecules. A series of krypto-BODIPY and meso-phenyl-BODIPY derivatives was synthesized, including eight new compounds such as mono- and di-halogenated scaffolds, acetylated analogues, Sonogashira coupling products, and a symmetric bis-BODIPY alkyne. The results demonstrate that both kryptopyrrole and meso-phenyl frameworks tolerate electrophilic substitution, C–H activation, and Pd-catalyzed cross-coupling reactions, enabling efficient diversification of BODIPY fluorophores. Overall, this work demonstrates the development of efficient synthetic strategies for biologically relevant and fluorescent molecular scaffolds, contributing new compounds and methodologies with potential applications in medicinal chemistry and chemical biology.
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Por uma educação pluriepistêmica : literatura indígena na formação de educadoras(es) na perspectiva decolonial
(Universidade Federal do Espírito Santo, 2026-02-10) Cerri, Thelma Chiarelli; Miranda, Marina Rodrigues ; https://orcid.org/0000-0002-1133-7827; https://lattes.cnpq.br/4087302830515226; https://orcid.org/0009-0002-9267-1073; https://lattes.cnpq.br/3064425025596625; Locatelli, Andrea Brandão ; https://orcid.org/0000-0001-7305-0787; https://lattes.cnpq.br/8754516218846670; Macedo, Roberto Sidnei Alves ; https://orcid.org/0000-0002-5350-5999; https://lattes.cnpq.br/4548303459275924
This study aimed to conduct research in Basic Education, using Literary Circles of Indigenous authors as formative devices grounded in their epistemologies and cosmologies, contributing to the transformation of educational processes toward the emergence of decolonial knowledge. The research examined the influence of colonial thought on the ideological framework of educators at the Francisco José Mattedi Municipal School of Integral Rural Education, as well as possible multi-epistemic pedagogical connections. Dialogues were established with the teaching staff in order to engage with theoretical perspectives rooted in decolonial cultural studies. The study draws on the contributions of Anibal Quijano (2005), Catherine Walsh (2018), Walter Mignolo (2003), and Paulo Freire (2022), among others, whose work supports the deconstruction of colonizing practices rooted in hegemonic Eurocentric thought. Methodologically, the research adopted a qualitative approach, developed through an ethnographic study based on participant observation of pedagogical practices at the school. As a research instrument, dialogical cycles were organized as a field of study involving both teachers and students from the school community. This methodological framework incorporated the political principles of Indigenous affirmation established by Brazilian Law No. 11.645/2008, which mandates the teaching of Indigenous History and Culture in Brazilian education. The dialogical processes were grounded in situated theoretical perspectives and enriched by Indigenous authors such as Smith (2021), Dorrico (2018), Graúna (2013), Krenak (2022), as well as the literary circularity proposed by Yamã (2012) and Miranda (2012, 2021, 2022, 2023, 2024). These engagements fostered alternative imaginaries of Indigenous knowledge production and cultivated, among students and educators, a critical awareness informed by decolonization and the de-standardization of a still rigid Basic Education curriculum. The study advocates for a curricular framework aligned with cultural specificities and constructed through dialogue with the school community, articulating ancestral knowledge with contemporary knowledge, and integrating principles of Popular Rural Education and Indigenous Education in order to promote collective well-being