Identificação de potenciais biomarcadores genéticos da rede de inflamação e seus riscos de desenvolver dispneia pós-COVID-19
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Data
2024-02-24
Autores
Ventorim, Vinicius do Prado
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Universidade Federal do Espírito Santo
Resumo
The study aimed to identify genetic biomarkers associated with the progression of dyspnea in individuals post-COVID-19. Following approval by the Research Ethics Committee (CEP), a case-control study was conducted involving 277 individuals. Participants were selected based on clinical and epidemiological criteria, allowing a representative sample of the study population. For genetic analysis, whole-exome sequencing was performed, the identification of genetic variants potentially associated with the clinical outcome. Rigorous statistical methodologies were applied to select the most relevant variants, focusing on determining the allelic risk for the progression of dyspnea. The prevalence of dyspnea among participants was 15.16%, underscoring the importance of investigating genetic factors that may influence its manifestation. Eleven genetic variants with p-values lower than 0.05 were identified, suggesting a statistically significant association with the risk of dyspnea progression. The identified variants are located in ten genes that play key roles in the immune system, in the regulation of vascular hemostasis, and in the response to epithelial damage. These findings indicate that genetic predisposition may contribute to the persistence of dyspnea in individuals who have overcome the acute phase of COVID 19. Gene analysis revealed a strong correlation with critical biological processes in the inflammatory response and tissue recovery. The immune system plays a central role in regulating the persistent inflammation observed in some post-COVID-19 individuals, and may influence the maintenance of chronic cardiorespiratory symptoms. Vascular hemostasis, on the other hand, may be associated with coagulation disorders previously described in patients with COVID-19, impacting pulmonary perfusion and contributing to dyspnea. Genes related to epithelial damage are possibly involved in lung tissue repair, being decisive for the functional recovery of the organ after infection. These results provide valuable directions for future clinical and epidemiological research in the State of Espírito Santo (Brazil). The identification of genetic biomarkers can help in the risk stratification of patients, allowing for more personalized and targeted therapeutic approaches. Moreover, the findings reinforce the need for further investigations to understand the mechanisms by which these genetic variants influence the evolution of post-COVID-19 dyspnea. Furthermore, this study contributes to the growing body of knowledge regarding sequelae of COVID-19 and its genetic bases, highlighting the importance of the integration between genomics and epidemiology for the development of public health strategies. Based on these findings, it is expected that further research can validate the identified biomarkers and deepen the understanding of the genetic factors involved in the recovery of post COVID-19 patients. This approach may, ultimately, lead to the development of more effective interventions to mitigate the impacts of persistent dyspnea on the quality of life of affected individuals
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Pós-COVID-19 , Dispneia , Caso-controle , Exoma , Variantes , Brasil , Post-COVID-19 , Dyspnea , Case-control , Exome , Variants , Brazil