Mestrado em Nutrição e Saúde

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http://repositorio.ufes.br/handle/10/17583

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Navegando Mestrado em Nutrição e Saúde por Autor "Barauna, Valério Garrone"

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    Ângulo de fase e índices de prognóstico inflamatório e nutricional em mulheres submetidas à cirurgia bariátrica
    (Universidade Federal do Espírito Santo, 2018-05-23) Koehler, Kymberle Betzel; Pedrosa, Rogério Graça; Haraguchi, Fabiano Kenji; Salaroli, Luciane Bresciani; Barauna, Valério Garrone
    Introduction: Bariatric surgery is indicated as a treatment for severe obesity, and nutritional assessment in the first six months after surgery is imperative, given the acute weight loss that can occur in this period. Phase angle (PA) is indicated as an indicator of nutritional status and prognosis, and inflammatory and nutritional prognostic indexes have been used to evaluate patients in several clinical situations. The relationship between PA and inflammatory and nutritional prognostic indexes is poorly understood, especially in bariatric patients. The aim of this study was to evaluate PA and its correlation with inflammatory and nutritional prognostic indexes in women submitted to Roux-en-Y gastric by-pass (RYGB). Methods: The study was performed with female patients of the Bariatric Surgery Program of the Cassiano Antonio Moraes University Hospital. The patients were evaluated in three moments: approximately one month before surgery (M0), and approximately two (M1) and sixth (M2) months after surgery. The following parameters were evaluated: body weight, height, body mass index (BMI), PA, serum concentrations of prealbumin, albumin, Creactive protein (CRP), and alpha-1-acid glycoprotein (α1-AG), the CRP/Albumin Ratio and the Prognostic Inflammatory and Nutritional Index (PINI). Data were analyzed using the Shapiro-Wilk Normality Test, one-way ANOVA test for repeated measurements with Sidak post hoc, and Pearson or Spearman correlations, depending on the nature of the data. Results: Body weight and BMI decreased significantly over the evaluated periods (P <0.05). The PA had a significant reduction over the evaluated periods, with values in M1 and M2 differing from M0. Serum concentrations of pre-albumin, CRP and α1-AG were significantly reduced over time, with concentrations in M1 and M2 differing from M0 (P <0.05). The CRP/albumin ratio showed a significant reduction over time, with M1 and M2 being different from M0 (P <0.05). The PINI did not show statistically significant alterations, but indicated a change in the classification of low risk of complications for no infection / inflammation, demonstrating an improvement in the prognosis of these patients. There was a very strong correlation between PINI and the CRP/albumin ratio (r = 0.96, P <0.001). There was no significant correlation between PA and prognostic indexes, however, a direct strong correlation between PA and pre-albumin serum concentrations (r = 0.63, P <0.01) was observed, which remained moderate in M0 ( r = 0.55, P = 0.01) and M1 (r = 0.57, P <0.01), suggesting the use of AF as an indicator of nutritional status during the perioperative period of women submitted to RYGB. Conclusion: PA decreased and inflammatory and nutritional prognosis improved. PA did not correlate with improvement in the prognosis indicated by the indexes, however, the strong correlation between PA and pre-albumin serum concentrations suggests its applicability in the evaluation of nutritional risk after RYGB and reinforces its use as an alternative tool to evaluate the nutritional status.
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    Identificação de alterações bioquímicas no soro de indivíduos submetidos à gastroplastia redutora em Y de Roux por espectroscopia no infravermelho médio
    (Universidade Federal do Espírito Santo, 2024-06-11) Bortoli, Amanda Motta de; Barauna, Valério Garrone; https://orcid.org/0000-0003-2832-0922; http://lattes.cnpq.br/; Haraguchi, Fabiano Kenji; https://orcid.org/0000-0002-1019-8888; http://lattes.cnpq.br/; Orientador2; https://orcid.org/; http://lattes.cnpq.br/; https://orcid.org/; http://lattes.cnpq.br/; Campos, Luciene Cristina Gastalho; https://orcid.org/; http://lattes.cnpq.br/; Rodrigues, Lívia Carla de Melo; https://orcid.org/; http://lattes.cnpq.br/; Leal, Leonardo Barbosa; https://orcid.org/; http://lattes.cnpq.br/; Nascimento, Márcia Helena Cassago; http://lattes.cnpq.br/
    Bariatric surgery, especially Roux-en-Y gastric bypass (RYGB), is the most indicated treatment for severe obesity, promoting significant biochemical alterations. Fourier transform infrared vibrational spectroscopy (FTIR) has been applied in biological analyses with the potential to detect such changes. This study investigated the use of FTIR for identifying biochemical alterations in the serum of individuals undergoing RYGB. An observational and descriptive study was conducted with patients from the Bariatric and Metabolic Surgery Program of a university hospital, before (T0) and approximately two months after RYGB (T1). Biochemical parameters, anthropometric data, and body composition were evaluated. FTIR spectra were recorded using ALPHA II equipment (Bruker, Germany), pre-processed, and subjected to Principal Component Analysis (PCA) and Partial Least Squares Discriminant Analysis (PLS-DA) (MATLAB 2023b). Data normality was tested using the Kolmogorov-Smirnov test, followed by paired T-test or Wilcoxon test. Spearman correlation analysis of spectral information with biochemical parameters was performed. A significance level of p <0.05 was adopted for all tests (GraphPad Prism 8 software). Twenty-nine individuals (86.2% female) with a mean age of 41.2 ± 7.8 years were evaluated. Anthropometric and body composition variables significantly decreased (p <0.001). Serum concentrations of albumin, transthyretin, C-reactive protein, alkaline phosphatase, glucose, triglycerides, total cholesterol, and LDL cholesterol also showed significant reductions (p <0.05). PCA demonstrated a trend of separation at T0 and T1 generated by biochemical alterations. Different significant correlations between biochemical parameters and spectral regions were identified at T0 and T1; however, only serum triglyceride concentration at both time points (p <0.05) correlated significantly with the spectral region characteristic of lipids (1796 - 1685 cm-1 ). The results suggest that FTIR exhibits sensitivity to identify alterations related to the lipid profile of individuals undergoing surgical treatment for severe obesity.