Alterações morfofuncionais de artérias intrapulmonares de ratos Wistar após intoxicação crônica por 60 dias ao cloreto de mercúrio

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dc.contributor.advisor-co1Simões, Maylla Ronacher
dc.contributor.advisor-co1IDhttps://orcid.org/0000-0003-1395-3938
dc.contributor.advisor-co1Latteshttp://lattes.cnpq.br/1541901247205779
dc.contributor.advisor1Vassallo, Dalton Valentim
dc.contributor.advisor1IDhttps://orcid.org/0000-0002-4463-4174
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/7749285591179880
dc.contributor.authorSchereider, Ingridy Reinholz Grafites
dc.contributor.authorIDhttps://orcid.org/0000-0002-6379-4050
dc.contributor.authorLatteshttp://lattes.cnpq.br/4495382135988623
dc.contributor.referee1 Santos, Leonardo dos
dc.contributor.referee1IDhttps://orcid.org/0000000243406364
dc.contributor.referee1Latteshttps://lattes.cnpq.br/4132087001362623
dc.contributor.referee2Fabiano Elias Xavier
dc.contributor.referee2IDhttps://orcid.org/0000-0003-2028-2562
dc.contributor.referee2Latteshttp://lattes.cnpq.br/4166941401353957
dc.contributor.referee3Davel, Ana Paula
dc.contributor.referee3IDhttps://orcid.org/0000-0002-9862-4262
dc.contributor.referee3Latteshttp://lattes.cnpq.br/0575590472541198
dc.contributor.referee4Lopes, Andressa Bolsoni
dc.contributor.referee4IDhttps://orcid.org/0000000312445667
dc.contributor.referee4Latteshttps://lattes.cnpq.br/0097480808041638
dc.date.accessioned2026-01-23T23:02:15Z
dc.date.available2026-01-23T23:02:15Z
dc.date.issued2025-10-09
dc.description.abstractMercury exposure is a significant public health concern due to its toxic potential in the human body, especially on the cardiovascular system. Its accumulation in the body induces oxidative stress, inflammation, and endothelial dysfunction in systemic arteries, contributing to the development of cardiovascular diseases. The close relationship between systemic and pulmonary circulation leads us to believe that the latter also suffers from the toxic effects of mercury. However, the consequences of HgCl₂ in the pulmonary arteries remain unclear. This study aimed to investigate the effects of mercury chloride (HgCl₂) exposure for 60 days on the small intrapulmonary arteries and hemodynamic parameters of male rats. The rats were exposed to HgCl₂ (1st dose, 4.6 μg/kg; subsequent daily doses, 0.07 μg/kg; intramuscular injection). The results revealed that intrapulmonary arteries from exposed rats exhibited reduced contractile responses to potassium chloride and the thromboxane A2 receptor agonist U46619, and arterial wall thinning, indicative of vascular hypotrophic remodeling. The impaired pulmonary vasoconstriction of the HgCl2 group was associated with increased nitric oxide (NO) and hydrogen peroxide (H₂O₂) levels. In addition, increased production of superoxide anion (O₂•-) and reduced superoxide dismutase (SOD) expressions. These findings suggest that chronic HgCl2 exposure induces pulmonary vascular dysfunctions, primarily through enhanced NO and ROS signaling as an adaptive mechanism against oxidative stress
dc.description.resumoresumo
dc.description.sponsorshipCNPq
dc.formatText
dc.identifier.urihttp://repositorio.ufes.br/handle/10/20825
dc.languagepor
dc.language.isopt
dc.publisherUniversidade Federal do Espírito Santo
dc.publisher.countryBR
dc.publisher.courseDoutorado em Ciências Fisiológicas
dc.publisher.departmentCentro de Ciências da Saúde
dc.publisher.initialsUFES
dc.publisher.programPrograma de Pós-Graduação em Ciências Fisiológicas
dc.rightsopen access
dc.subjectArtéria pulmonar
dc.subjectMercúrio
dc.subjectEstresse oxidativo
dc.subjectDisfunção endotelial
dc.subjectReatividade vascular.
dc.subject.cnpqFisiologia
dc.titleAlterações morfofuncionais de artérias intrapulmonares de ratos Wistar após intoxicação crônica por 60 dias ao cloreto de mercúrio
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