Mestrado em Assistência Farmacêutica

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Ansiedade e depressão entre estudantes da Universidade Federal do Espírito Santo após o retorno ao ensino presencial durante a pandemia por COVID-19
(Universidade Federal do Espírito Santo, 2023-04-19) Silva, Bruna Martins; Ayres, Lorena Rocha; https://orcid.org/0000-0003-4346-5281; http://lattes.cnpq.br/9912356382327501; http://lattes.cnpq.br/4224871570223139; Aguiar, Patrícia Melo; https://orcid.org/0000-0002-3957-4533; http://lattes.cnpq.br/3675846651594296; Reis, Walleri Christini Torelli; https://orcid.org/0000-0001-6911-4792; http://lattes.cnpq.br/2753628629224141
Introduction. The pandemic of the disease caused by the new coronavirus (COVID-19) has led to changes in the behavior and routine of university students, which has had an impact on the development of a series of common mental disorders, such as anxiety and depression. Despite the impact of these disorders on academic performance, to date, there are no studies investigating this issue among Brazilian university students after returning to face-to-face teaching. Goal. Understanding aspects related to anxiety and depression symptoms in university students after returning to face-to-face teaching during the COVID-19 pandemic. Method. This is a cross-sectional, quantitative study, carried out between July 2022 and August 2022. University students, over 18 years old, linked to the Federal University of Espírito Santo (UFES) were included in the research. Sampling was carried out for convenience and data collection was performed through a questionnaire, implemented on the SurveyMonkey online platform. Sociodemographic data and data related to the use of pharmacological and non-pharmacological measures used to treat anxiety and depression symptoms in university students were collected. In addition, students answered the screening and severity measurement questionnaires for symptoms of anxiety and depression: General Anxiety Disorder (GAD-7) and Patient Health Questionnaire-9 (PHQ-9), respectively. Data were analyzed using descriptive and inferential statistics. This work was approved by the Ethics Committee for Research with Human Beings and all participants signed the Free and Informed Consent Term (TCLE). Results. 1103 students participated in the study. Based on the results of the GAD-7 and PHQ-9 scales, it was observed that 8.3% (n=92) of the students had scores compatible with anxiety, 14.7% (n=162) with scores compatible with depression, and 56 .7% (n= 625) scores compatible with anxiety and depression simultaneously. 1103 students participated in the study. Based on the results of the GAD-7 and PHQ-9 scales, it was observed that 8.3% (n=92) of the students had scores compatible with anxiety, 14.7% (n=162) with scores compatible with depression, and 56 .7% (n= 625) scores compatible with anxiety and depression simultaneously. In addition, 422 (38.3%) of the students had thoughts related to self-harm or suicide in the last fifteen days. It was observed that 37% (n=409) of the participants reported having a previous diagnosis of anxiety and/or depression. Regarding the treatment of anxiety and depression, 62.3% (n=255) of the students reported using pharmacological measures, such as selective serotonin reuptake inhibitors (64.2%; n=164), benzodiazepines (45, 1%; n=115) and serotonin and noradrenaline reuptake inhibitors (23.5%; n=60) were the most mentioned, while 36.7% (n=150) use psychotherapy, 14.9% (n=61) meditation and 6.4% (n=26) yoga. Conclusion. Through the data found, it can be concluded that the COVID-19 pandemic had an impact on the mental health of university students, providing a high frequency of scores compatible with anxiety and/or depression and increasing the search for pharmacological management to relieve the symptoms of these disorders, which is why it is essential for the university to engage in guaranteeing the protection, promotion and recovery of students' mental health during and after the COVID-19 pandemic.
Avaliação do impacto do acompanhamento farmacoterapêutico a pessoas com hipertensão arterial em um município sul-capixaba : ensaio clínico pragmático
(Universidade Federal do Espírito Santo, 2024-03-15) Alencar, Taiana de; Santos Júnior, Genival Araujo dos ; https://orcid.org/0000-0002-5618-1846; http://lattes.cnpq.br/5917097187533724; https://orcid.org/0009-0006-1916-9633; http://lattes.cnpq.br/7190658443957873; Oliveira Filho, Alfredo Dias de; https://orcid.org/0000-0003-3192-8285; http://lattes.cnpq.br/2692375096980574; Severi, Juliana Aparecida; https://orcid.org/0000-0001-7516-2395; http://lattes.cnpq.br/4265400222421660 ; Silva, Rafaella de Oliveira Santos; https://orcid.org/; http://lattes.cnpq.br/4008596465243842
Introduction: Arterial hypertension (AH) is a chronic health condition that may require changes in lifestyle and the use of medication. However, this use is not without risks. In this context, the Pharmacotherapeutic Follow-up Service (FHS) has emerged as a strategy capable of improving the health outcomes of people with AH. However, there are few high-research studies on this subject. Objective: To assess the impact of FAS on the health outcomes of patients with AH in the health care network in the municipality of Alegre/ES. Method: This is an experimental single-blind randomized controlled clinical trial. People with hypertension who met the eligibility criteria (over 18 years of age, with self-reported hypertension, taking medication for hypertension for at least 6 months) were randomized in a 1:1 ratio to the intervention and control groups. They received FAS and usual care, respectively, for a period of 12 months. The study was conducted in the Health Care Network of the municipality of Alegre, Espírito Santo, Brazil, from January 2022 to November 2023. In both groups, primary outcomes (blood pressure and quality of life) and secondary outcomes (knowledge about hypertension, anthropometric profile and clinical examinations) were assessed at three points in time, six months apart. Ethical considerations were observed (CAAE registration number 13586319.6.0000.8151 | Opinion no. 4.732.878). Results: 128 patients were allocated to the intervention group (64) and the control group (64). Statistically significant differences were observed in the intra-group analysis in the intervention group, including SBP (∆ = -9.47 mmHg, p = 0.014), Total Cholesterol (∆ = -18.93 mg/dL, p = 0.001), LDL (∆ = -15.70 mg/dL, p < 0.001), non-HDL cholesterol (∆ = -19.76 mg/dL, p < 0.001) and cardiovascular risk (∆ = -1.82 points, p < 0.001). There was an increase in the score for knowledge about hypertension (∆ = 1.39 points, p < 0.001), an improvement in quality of life in the mental state subdimension (∆ = -2.76 points, p = 0.020) and somatic manifestations (∆ = -1.5 points, p = 0.012). In the control group, it was possible to observe an increase in the score for knowledge about hypertension (∆ = 1.52 points, p = 0.001) and an improvement in the VAS of the EQ5D (∆ = 10.33 points, p = 0.067). In addition, almost all the patients were satisfied or very satisfied with the service provided by the pharmacists. Conclusion: The results show a promising positive impact of FAS on clinical and humanistic parameters, as well as a reduction in cardiovascular risk for negative events over the next ten years. This study was registered with The Brazilian Clinical Trials Registry (ReBEC) under registration number: RBR-4c53f3m.
Avaliação epidemiológica e econômica do tratamento em primeira linha com medicamentos modificadores do curso da doença sintéticos convencionais para artrite psoriásica
(Universidade Federal do Espírito Santo, 2022-11-09) Faria, Ronaldo José; Silva, Michael Ruberson Ribeiro da; https://orcid.org/0000000325507249; http://lattes.cnpq.br/2822520981120774; https://orcid.org/0000-0003-0650-128X; http://lattes.cnpq.br/2630619230642585; Ignacchiti, Mariana Drummond Costa; https://orcid.org/0000-0003-3768-949X; http://lattes.cnpq.br/0533640513430050; Gomes, Rosângela Maria; https://orcid.org/0000-0001-8299-4835; http://lattes.cnpq.br/8395018794734460
Conventional synthetic disease course modifying drugs are the first-line treatment to inhibit the progression of psoriatic arthritis. Despite their wide clinical use, few studies have been conducted to compare these drugs for the treatment of psoriatic arthritis. In this regard, an observational study was conducted to identify the profile of use and expenditures with these drugs in a real-life setting. A longitudinal study was conducted from a national centralized patient database in Brazil. Patients with psoriatic arthritis who obtained their first synthetic disease-modifying drug through SUS were included. The market share of the drugs, persistence in treatment, drug costs, and cost per response, considered as the cost per persistent patient were evaluated. Results: a total of 1,999 individuals with psoriatic arthritis were included. Methotrexate was the most commonly used drug (44.4%), followed by leflunomide (40.6%), cyclosporine (8.2%), and sulfasalazine (6.8%). Methotrexate and leflunomide had a higher market share compared to cyclosporine and sulfasalazine over the years. Treatment persistence was highest for leflunomide (58.9% and 28.2%), followed by methotrexate (51.6% and 25.4%) at six and 12 months, respectively. Leflunomide was found to be the most expensive drug, with an average annual cost of R$ 749.67, followed by sulfasalazine (R$ 251.58), cyclosporine (R$ 230.73), and methotrexate (R$ 95.06). Methotrexate was the drug with the lowest cost per response. Methotrexate had the best cost-perresponse ratio due to its lower cost and a slightly lower proportion of persistent patients when compared with leflunomide, which supports its current use as a first drug indicated in the treatment of psoriatic arthritis. Leflunomide showed greater treatment persistence, however, it was the most expensive drug.
Estudo de utilização de medicamentos em indivíduos residentes no município de Alegre-ES: achados e implicações
(Universidade Federal do Espírito Santo, 2022-12-21) Bazoni, Patrícia Silva; Silva, Michael Ruberson Ribeiro da; https://orcid.org/0000000325507249; http://lattes.cnpq.br/2822520981120774; https://orcid.org/0000-0002-3829-4900; http://lattes.cnpq.br/6643287346058686; Meira, Eduardo Frizzera; https://orcid.org/0000-0002-0210-4319; http://lattes.cnpq.br/9651828257315064; Gomes, Rosângela Maria; https://orcid.org/0000-0001-8299-4835; http://lattes.cnpq.br/8395018794734460
The use of drugs as a therapeutic resource has evolved a lot throughout human history, becoming the main technological instrument in the field of health. In addition, they can provide several benefits to the user's health, however, when used incorrectly and unnecessarily, they can trigger several damages to the patient's health. In this context, the objective of this study was to analyze the profile of medication use, prevalence and factors associated with the occurrence of polypharmacy and self-medication in the population of Alegre, Espírito Santo. An epidemiological study with a cross-sectional design was carried out, using a household survey, in the city of Alegre, between November and December 2021. A descriptive analysis of sociodemographic and clinical characteristics was carried out, as well as the prevalence of polypharmacy and self-medication. of the interviewees. In this study, the occurrence of minor polypharmacy was defined as the use of two to four medications and major polypharmacy as the use of five or more medications. The occurrence of selfmedication was defined as the use of medication on one's own to treat self-recognized health problems. Factors associated with self-medication were assessed using Poisson regression and factors associated with minor and major polypharmacy using logistic regression. The prevalence of minor polypharmacy was 44.9% and of major polypharmacy was 20.2%. Additionally, it was found that 69.4% of respondents practiced self-medication. Factors associated with lower polypharmacy were: older age group, female gender, self-declared white, worse quality of life, medical appointments in the last year, use of the Municipal Basic Pharmacy and presence of comorbidities. On the other hand, the factors associated with major polypharmacy were the same as minor polypharmacy, with the exception of the gender variable and having only one disease when compared with patients who had two or more diseases. In addition, higher income, fair and poor/very poor self-perception of health, not self-medicating, problems with adherence to treatment and not using medicinal plants were factors associated with the occurrence of higher polypharmacy. The factors associated with the occurrence of self-medication were younger age, female sex, consumption of alcoholic beverages, problems with adherence to pharmacotherapy and, as a protective factor, being in greater polypharmacy. The results of this study can contribute to the optimization of patient care, reinforce the need for health education actions and the search for the rational use of medicines, as well as provide subsidies for public policies to promote health.
Impacto do serviço de acompanhamento farmacoterapêutico nos desfechos em saúde de pacientes com hipertensão arterial: protocolo de ensaio clínico e dados preliminares
(Universidade Federal do Espírito Santo, 2023-08-21) Vieira, Maria Paula Debona; Santos Junior, Genival Araújo dos; https://orcid.org/0000000256181846; http://lattes.cnpq.br/5917097187533724; https://orcid.org/0009-0003-0261-6239; http://lattes.cnpq.br/6124466867030276; Borba, Helena Hiemisch Lobo; https://orcid.org/0000-0001-9723-584X; http://lattes.cnpq.br/9205414489911034; Batista, Tatianne Mota; https://orcid.org/0000-0003-3240-2613; http://lattes.cnpq.br/2980899910202014
Introduction: Hypertension is a chronic health condition that usually requires the use of medication; however, this use is not risk-free. In this scenario, medication therapy management. is a strategy that can improve the health outcomes of people with hypertension. Despite this, there are few studies with high scientific evidence on this topic. Objective: To evaluate preliminary data on the impact of the Comprehensive Medication Therapy service on the health outcomes of patients with hypertension. Methods: This study was carried out in two stages. The first consisted of the elaboration of a protocol for a randomized clinical trial, from June to December 2021. The second stage was the preliminary six-month evaluation of patients with hypertension. The patients who met the eligibility criteria were randomly allocated in a 1:1 ratio to the intervention or control group, who received medication therapy management and usual care, respectively, for 12 months. Both groups had their primary outcomes (baseline blood pressure and quality of life) and secondary outcomes (knowledge about pharmacotherapy; knowledge about hypertension and medication adherence; anthropometric profile, and clinical outcomes) assessed at two time points with a six-month interval between them. Ethical considerations were observed (CAAE: 13586319.6.0000.8151 | Approval nº 4.732.878). Statistical analyzes were performed using Student's t test for independent samples, investigating the difference in the means of the outcomes evaluated between the intervention and control groups at T0 (baseline) and T6. Results: In the first stage, a single-blind randomized clinical trial protocol was proposed, following the recommendations of the Standard Protocol Items: Recommendations for Interventional Trials and the Consolidated Standards of Reporting Trials, which was registered in The Brazilian Clinical Trials Registry (ReBEC) (registration number RBR-4c53f3m). In the second stage, the preliminary evaluation showed that six months after the start of the study, no significant differences were found in any of the studied variables when comparing the control group and the intervention group. However, when performing intragroup analyses, it was possible to observe that patients in the intervention group had improvements in laboratory tests and quality of life after six months of follow-up, with a decrease in systolic blood pressure (-8.50 mmHg, p=0.04), total cholesterol (-11.94 mg/dL, p=0.05), and LDL (-12.21 mg/dL, p=0.01). They also had an increase in knowledge about hypertension (1.62, p=0.001), and improvement in quality of life (MINICHAL) in two parameters, mental (2.79 p=0.02) and somatic manifestations (1.62 p=0.03). Conclusion: In the preliminary 6-month analysis, statistically significant differences were found when comparing the control and intervention groups. The changes observed in the intervention group indicate a positive outcome related to the pharmacotherapeutic follow-up service, with the potential for further improvement in the results when the analysis is performed at 12 months.
Perfil clínico e humanístico de pacientes com hipertensão arterial da Rede de Atenção à Saúde de um município no Sul-Capixaba
(Universidade Federal do Espírito Santo, 2023-08-11) Mendes, Mayra Cardozo; Santos Júnior, Genival Araujo dos; https://orcid.org/0000000256181846; http://lattes.cnpq.br/5917097187533724; https://orcid.org/0009-0003-4358-6603; http://lattes.cnpq.br/6949871999044526; Santana, Rafael Santos; https://orcid.org/0000-0003-4481-210X; http://lattes.cnpq.br/6970798378260844; Santos, Sabrina Cerqueira; https://orcid.org/0000-0001-6748-727X; http://lattes.cnpq.br/8757541282986479
Introdução. Hypertension is the most prevalent chronic condition in primary care and the leading preventable cause of cardiovascular death worldwide. However, information about the clinical and humanistic profile of individuals with hypertension treated in a municipality in southern Espírito Santo, Brazil, is limited. Objective. To characterize the clinical and humanistic profile of patients with Arterial Hypertension within the healthcare network of a municipality in southern Espírito Santo. Method. A descriptive cross-sectional study with a quantitative approach conducted between January 2022 and July 2022 in the municipality of Alegre-ES. Study participants were individuals over 18 years of age, diagnosed with hypertension, and using at least one medication for hypertension. Data collection was performed using a structured form created by the author. Sociodemographic data, anthropometric profile, lifestyle, clinical profile, and pharmacotherapeutic profile were collected. Adherence to pharmacotherapy, knowledge about hypertension, overall quality of life, and quality of life related to hypertension were assessed using validated questionnaires. The study was approved by the Ethics Committee of the Federal University of Espírito Santo (CAAE: 13586319.6.0000.8151). Data were presented using descriptive statistics. Results: The study included 129 participants, of whom 74.41% (n=96) were women, with an average age of 59.83 ± 11.15 years, married (58.13%; n=75), self-identified as non-white (73.64%; n=95), did not engage in physical activity (75.2%; n=97), denied alcohol consumption (80.6%; n=104) and nicotine use (60.5%; n=78), and reported having two or more health conditions (69.76%; n=90). Women had an average weight of 75.16 ± 14.24 kg, and men had an average weight of 77.86 ± 13.79 kg. In clinical data, the lipid profile showed that 47.29% (n=61) had total cholesterol and 48.84% (n=63) had triglycerides above recommended levels. Regarding blood pressure, 34.89% (n=45) had systolic blood pressure greater than 140 mmHg, and 25.58% (n=33) had diastolic blood pressure greater than 90 mmHg. The majority were on polypharmacy (58.91%; n=76), and treatment adherence was considered high in 86.82% (n=123) of evaluated patients. Furthermore, 50.38% (n=65) had good knowledge about hypertension, and 68.22% (n=88) stated that hypertension does not influence their quality of life. Conclusion. Most participants exhibited clinical profiles in line with guidelines and clinical protocols, as well as positive results for the humanistic profile, potentially contributing to future studies.
Perspectivas dos profissionais de saúde quanto aos cuidados da população transgênero na Atenção Primária à Saúde: uma revisão de escopo
(Universidade Federal do Espírito Santo, 2025-03-20) Souza, Jayne Menezes de; Detoni, Kirla Barbosa; https://orcid.org/0000-0003-0651-3547 ; http://lattes.cnpq.br/4658617742317519; Rocha, Kérilin Stancine Santos; https://orcid.org/0000-0002-2313-2140 ; http://lattes.cnpq.br/4216594263272412; https://orcid.org/0009-0002-6619-6977; http://lattes.cnpq.br/0195480308196211; Brito, Giselle de Carvalho; https://orcid.org/0000-0002-3982-2138; http://lattes.cnpq.br/0432751118102432; Jesus, Náila Neves de; https://orcid.org/0000-0003-3370-0639; http://lattes.cnpq.br/6566671970631957; Santos Júnior, Genival Araújo dos; https://orcid.org/0000-0002-5618-1846; http://lattes.cnpq.br/5917097187533724; Araújo, Dyego Carlos Souza Anacleto de; https://orcid.org/0000-0001-6631-465X; http://lattes.cnpq.br/5120426619544250; Santos, Sabrina Cerqueira ; https://orcid.org/0000-0001-6748-727X; http://lattes.cnpq.br/8757541282986479
Introduction: Studies show that transgender individuals face significant barriers in the context of primary health care. The literature has explored the perspectives and experiences of transgender individuals regarding the care they receive; however, there is still no comprehensive view of health professionals' perspectives on this care. Objective: To map the perspectives of health professionals regarding the care of the transgender population in primary health care. Methods: A scoping review was conducted following the methodological processes proposed by the JBI Manual for Evidence Synthesis and the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR). A systematic search was carried out in May 2024 in the following databases: PubMed/Medline, Embase, Web of Science, Cinahl, Scielo, Virtual Health Library, the International Journal of Transgender Health, and the gray literature. Descriptors related to "Health Personnel," "Transgender Persons," and "Primary Health Care" were used. Subsequently, two reviewers independently selected the studies through title and abstract screening, followed by full-text analysis based on eligibility criteria. Data were extracted independently by two reviewers, and the professionals' perspectives were jointly analyzed by the review team and categorized. The data were presented descriptively. Results: A total of 1,022 studies were identified in the initial search, of which 11 articles met the eligibility criteria and were included in this review. Most studies were conducted in North American countries (n = 7; 63.6%) and had a qualitative design (n = 9; 81,8%). The analysis of healthcare professionals' perspectives resulted in the following categories: "Professional Attitude," addressed in 11 studies (100%), "Healthcare Network" (n = 10; 90,9%), "Training" (n = 9; 81,9%), and "Stigma" (n = 7; 63,3%). The main professionals participating in the studies were physicians and nurses. Strategies cited by professionals for promoting transgender care in primary health care focused on the professional and/or the healthcare team. Conclusion: The perspectives of professionals on the care of the transgender population in primary health care revealed that various aspects related to the Health Care Network, Training, Stigma, and Professional Attitudes influence this care. Significant challenges were identified, which may compromise the quality of care. Strategies focused on professionals and teams can be implemented to promote inclusive care
Produção de vídeos de educação em saúde para surdos : uma revisão de escopo
(Universidade Federal do Espírito Santo, 2024-08-01) Salomão, Sthefany Brito; Bassan, Larissa Helyne ; https://orcid.org/0000-0002-6460-7878; http://lattes.cnpq.br/8455348679035377; Araújo, Dyego Carlos Souza Anacleto de ; https://orcid.org/0000-0001-6631-465X; http://lattes.cnpq.br/5120426619544250; https://orcid.org/0009-0008-8743-8780; http://lattes.cnpq.br/5011148219460466; Nunes, Deuzilane Muniz ; https://orcid.org/0000-0002-3037-2660; http://lattes.cnpq.br/9351254036991427; Galindo Neto, Nelson Miguel ; https://orcid.org/0000-0002-7003-165X; http://lattes.cnpq.br/0593074026473891
Introduction: deaf people face barriers to communication and access to health information. Sign Language videos are effective tools for transmitting this information. However, there is no synthesis in the literature about the production process of these videos. Objective: to summarize the steps in the process of producing health education videos for the deaf. Methods: this is a scoping review, carried out in accordance with the recommendations of the JBI Manual for Evidence Synthesis for Scoping Reviews. The searches were carried out in December 2023, in PubMed/Medline, Embase, Scopus, Lilacs, Scielo and Google Scholar, using descriptors related to “deafness” and “health education”. Two researchers independently selected studies, by analyzing titles and abstracts and then full texts. Original studies were included, whose main objective was to develop and/or evaluate health education videos for the deaf, as long as the stages of the production process were described. The following articles were extracted: authors, year of publication, country, theme and steps and guidelines for producing educational video material for the deaf. Results: 1809 publications were identified in the initial search, of which 16 were included in this scoping review. The articles were published between 2009 and 2023, with the United States (n=7; 43.8%) and Brazil (n=5; 31.2%) being the countries with the highest number. The educational videos were especially about breast cancer (n=3; 18.8%); Sexual and reproductive education (n=3; 18.8%) and oral hygiene (n=2; 12.5). The synthesis of the steps and guidelines identified in the studies were summarized and structured as follows: i) pre-production, which consists of planning the video; ii) production, which includes the construction and recording of videos; iii) post-production, which includes editing and organizing recorded scenes, as well as validating the material produced. Conclusion: this scoping review summarized the stages of the process of producing health education videos for the deaf available in the literature, and can be used as a starting point by health educators
Qualidade de vida relacionada à saúde e fatores associados em um município de pequeno porte durante a pandemia de COVID-19
(Universidade Federal do Espírito Santo, 2023-08-16) Pezzin, Josiane; Silva, Michael Ruberson Ribeiro da; https://orcid.org/0000000325507249; http://lattes.cnpq.br/2822520981120774; https://orcid.org/0009-0009-8339-0561; http://lattes.cnpq.br/9172067654108376; Bortoli, Valquíria Camin de; https://orcid.org/0000-0001-5801-8447; http://lattes.cnpq.br/3992098322056730; Gomes, Rosângela Maria; https://orcid.org/0000-0001-8299-4835; http://lattes.cnpq.br/8395018794734460
Quality of Life (QL) is about the individual's perception of their position in life in the context of the culture and value systems in which they live and in relation to their goals, expectations, standards and concerns. For healthcare applications, the term HealthRelated Quality of Life (HRQoL) is often used. Research in this area is of great relevance to aid in the development of public policies, evaluation of outcomes in clinical trials and economic analysis. However, population-based research on HRQoL, conducted in different sociocultural settings, is scarce. In this sense, this work aimed to evaluate HRQoL and its associated factors in a small brazilian municipality during the period of the COVID-19 pandemic. This is an epidemiological, cross-sectional, population-based study carried out through a household survey, during the period from november to december 2021 in the city of Alegre/ES, Brazil. The sample was representative of the city's urban population and consisted of individuals aged ≥ 18 years. Through face-to-face interviews, self-reported sociodemographic data, life habits, health-related characteristics, comorbidities and an assessment of HRQoL were collected using the EQ-5D-3L instrument. Data were submitted to statistical analysis and presented in the form of graphs and tables. The association between HRQoL levels and the explanatory variables collected using the Tobit regression model was tested. The study was approved by the UFES Research Ethics Committee under Opinion nº 3,428,060. 694 individuals were interviewed, predominantly female (72.9%) and mean age was 53 years (SD = 18.9). The most prevalent comorbidities were high blood pressure and anxiety. In the analysis of the EQ-5D, 43.23% of the interviewees reported the absence of problems in all dimensions. The dimension with the highest frequency of problems was pain/discomfort, followed by anxiety/depression. The mean HRQoL value obtained was 0.818 (SD = 0.195) on the EQ-5D descriptive system and 77.8 (SD = 18.9) on the EQ-VAS visual analogue scale. The correlation between these values was positive and moderate. The factors that maintained an association with HRQoL in the final Tobit regression model (p ≤ 0.05) were: self-perceived health, disability, polypharmacy, hospitalization in the last year, anxiety, rheumatoid arthritis, obesity and medication adherence problems. In general, the influence of these factors on HRQoL is already well discussed in the literature, except for problems with medication adherence. Along with polypharmacy, this factor highlights the importance of strengthening pharmaceutical care services and multidisciplinary teams in health care in Alegre/ES. The profile of reporting problems in the dimensions of the EQ-5D3L is consistent with that found in national and international studies. The results of this study present a health assessment of a small municipality, useful for local health managers, and which enriches the literature in the area with data on HRQoL in settings and contexts that have been little studied.
Sintomas depressivos no ambiente universitário no contexto da pandemia por Covid-19: achados e implicações
(Universidade Federal do Espírito Santo, 2024-06-14) Peixoto, Meiriane; Meira, Fabiana Dayse Magalhães Siman; http://lattes.cnpq.br/9468453605243748; Silva, Michael Ruberson Ribeiro da; https://orcid.org/0000-0003-2550-7249; http://lattes.cnpq.br/2822520981120774; https://orcid.org/0000-0003-3981-395X; http://lattes.cnpq.br/8234350262120642; Marques, Luciene Alves Moreira; Barreto, Ana Claudia Gama
Introduction: Depression is the most common mental disorder and is considered the leading cause of disability and premature death worldwide. Data from the World Health Organization (WHO) reveal that over 322 million people are affected by depression. Recently, the COVID-19 pandemic has been considered a factor that can increase and/or exacerbate symptoms indicative of depression. As a result, the university population has been a target of study due to the significant impact that mental disorders have on academic life. Objective: To analyze the prevalence of depression among students and staff at Brazilian Higher Education Institutions (HEIs). Methods: The first phase is na epidemiological, observational, cross-sectional, analytical, individual study comprising public servants, undergraduates, and postgraduates from the Alegre campus of the Federal University of Espírito Santo, conducted from June to October 2020. Participants responded to an online questionnaire that included variables such as academic trajectory, sociodemographic data, lifestyle habits, health conditions, and the Beck Depression Inventory (BDI). The collected data were analyzed using descriptive statistics with the aid of SPSS® version 20. The second phase of the study involves a systematic literature review, registered in PROSPERO, conducted in the Medline via PubMed, LILACS, Scielo, and Embase databases using descriptors from Medical Subject Headings (MeSH), Health Sciences Descriptors (DeCS), and EMTREE terms, following the PRISMA guideline recommendations and the Joanna Briggs Institute Critical Appraisal tool for bias analysis of the publications. Cross sectional studies published in Portuguese, English, or Spanish, measuring the prevalence of depression among the university population, and published between 2020 and 2023 met the inclusion criteria. Subsequently, two independent researchers evaluated titles, abstracts, full texts, and extracted data. Results: The sample (first phase) comprised 519 participants: 15.6% faculty, 5.6% public servants, 71.5% students, and 7.3% postgraduates. The data revealed a high prevalence of depressive symptoms before the pandemic (37.4%) compared to the general population, with a significant increase during the pandemic period (44.9%) (p-value<0.05). The main risk factors associated with depressive symptoms were female sex and smoking. The majority of the population is female (68.2%), with 74.8% single, living in shared housing (40.7%), and with a predominant family income of 1 to 3 minimum wages (61.1%). Most participants are from the Center for Exact, Natural, and Health Sciences (CCENS), with the pharmacy course being the most represented (11.3%). In the systematic review, out of 96 identified records, 10 articles met the eligibility criteria. The studies were conducted in public and private universities across all regions of the country. The predominant methodological design was cross-sectional (n=9), with one study being a qualitative-quantitative investigation (n=1). The sample sizes ranged from 217 to 5985 participants, comprising undergraduates, postgraduates, and staff. The prevalence found ranged from 10.1% to 81.0%. Three studies analyzed undergraduates from health-related courses (pharmacy, dentistry, and medicine), and only one study analyzed all three populations together. The most commonly used instrument to assess prevalence was the Depression, Anxiety, and Stress Scale (DASS-21). Conclusion: The data presented in the first article reveal a high prevalence of depression in the university population at UFES Alegre campus, exacerbated during the pandemic period and associated with females and smokers. The systematic review data corroborated the findings of the first article regarding the pandemic period; however, the analyzed population included universities from across the country. Therefore, the results indicate the need for prevention, care and support measures for the academic and can be used to support future projects for university and public health policies to address the psychological distress of the university population.

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