Nutrição e Saúde

URI Permanente desta comunidade

http://repositorio.ufes.br/handle/10/17582
Programa de Pós-Graduação em Nutrição e Saúde

Centro: CCS
Telefone: (27) 3335 7017
URL do programa: http://www.nutricaoesaude.ufes.br/pt-br/apresenta%C3%A7%C3%A3o

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    A relação entre o ângulo de fase e a melhora do estado anti-inflamatório de indivíduos submetidos à gastroplastia redutora em Y de Roux
    (Universidade Federal do Espírito Santo, 2024-08-28) Gomes, Amanda Cristina Araujo; Lopes, Andressa Bolsoni ; https://orcid.org/; http://lattes.cnpq.br/; Co-orientador2; https://orcid.org/; http://lattes.cnpq.br/; Co-orientador3; https://orcid.org/; http://lattes.cnpq.br/; Co-orientador4; ID do co-orientador4; Lattes do co-orientador4; Haraguchi, Fabiano Kenji ; https://orcid.org/; http://lattes.cnpq.br/; Orientador2; https://orcid.org/; http://lattes.cnpq.br/; https://orcid.org/; http://lattes.cnpq.br/; Nunes, Karolini Zuqui ; https://orcid.org/; http://lattes.cnpq.br/; Rossoni Júnior, Joamyr Victor ; https://orcid.org/; http://lattes.cnpq.br/; 3º membro da banca; https://orcid.org/; http://lattes.cnpq.br/; 4º membro da banca; http://lattes.cnpq.br/; 5º membro da banca; https://orcid.org/; http://lattes.cnpq.br/; 6º membro da banca; https://orcid.org/; http://lattes.cnpq.br/; 7º membro da banca; https://orcid.org/; http://lattes.cnpq.br/
    Introduction: Obesity leads to a state of chronic inflammation, characterized by an increase in inflammatory cytokines and infiltration of immune cells in adipose tissue, which can contribute to cellular dysfunction. Phase Angle (PA) is a non-invasive measurement derived from electrical bioimpedance, which has been associated with cellular integrity and metabolic health, and may therefore reflect inflammatory changes in response to weight loss induced by bariatric surgery. Objective: To evaluate the relationship between phase angle and parameters indicative of inflammatory status in patients undergoing bariatric surgery. Methodology: Prospective, observational study carried out with 23 volunteer patients from the Bariatric and Metabolic Surgery Program at a University Hospital. Participants were assessed at three points in time: preoperatively, approximately one month before surgery (T0) and postoperatively, approximately the 2nd (T1) and 6th (T2) months after surgery. Body weight, BMI, waist circumference (WC), fat mass (FF), fat-free mass (FFM), % weight loss, PA, serum concentrations of C-Reactive Protein (CRP), acid alpha-1-glycoprotein (AGP), adiponectin, Tumor Necrosis Factor Alpha (TNF-α) and resistin were analyzed. The data was statistically analyzed using the Statistical Package for the Social Sciences - SPSS, version 21.0. The Shapiro-Wilk test was applied to test the normality of the data, analysis of variance for repeated measures (ANOVA or Friedman test) and Spearman or Pearson correlations between PA and biochemical parameters and body parameters. A significance level of p<0.05 was adopted. Results: There was a significant reduction in body weight, BMI, MG, GLM, WC and PA over the time points, with different values for body weight, BMI, WC and MG between the time points (p<0.001). The percentage of weight loss was higher at T2 (p<0.001). All the biochemical parameters evaluated decreased significantly over the time points, with serum concentrations of AGP, CRP and resistin decreasing at T1 (p<0.05), while serum concentration of TNF-α decreased only at T2 (p<0.05). Serum adiponectin concentration increased from T1 onwards (p<0.001).A negative correlation was observed between variations in serum adiponectin concentrations and variations in PA values throughout the study (r=-0.480, p=0.027) and a negative correlation between serum adiponectin concentration and BMI (r=-0.264, p=0.038) and MG (r=-0.277, p=0.029) values, regardless of time. A positive correlation between serum TNF-α concentrations and BMI (r=0.338, p=0.004) and MG (r=0.335, p=0.004) values was also observed, as was the presence of a positive correlation between serum resistin concentration and MG values (r=0.245, p=0.042). Conclusion: The data suggest that smaller reductions in PA may be associated with an improved anti-inflammatory state during weight loss after BS.
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    Adiposidade abdominal e sua relação com consumo alimentar, estresse e qualidade de vida de profissionais de segurança pública
    (Universidade Federal do Espírito Santo, 2024-04-10) Silva Neto, Luiz Claudio Barreto; Co-orientador1; https://orcid.org/; http://lattes.cnpq.br/; Co-orientador2; https://orcid.org/; http://lattes.cnpq.br/; Co-orientador3; https://orcid.org/; http://lattes.cnpq.br/; Co-orientador4; ID do co-orientador4; Lattes do co-orientador4; Orientador1; https://orcid.org/; http://lattes.cnpq.br/; Orientador2; https://orcid.org/; http://lattes.cnpq.br/; https://orcid.org/; http://lattes.cnpq.br/; 1º membro da banca; https://orcid.org/; http://lattes.cnpq.br/; 2º membro da banca; https://orcid.org/; http://lattes.cnpq.br/; 3º membro da banca; https://orcid.org/; http://lattes.cnpq.br/; 4º membro da banca; http://lattes.cnpq.br/; 5º membro da banca; https://orcid.org/; http://lattes.cnpq.br/; 6º membro da banca; https://orcid.org/; http://lattes.cnpq.br/; 7º membro da banca; https://orcid.org/; http://lattes.cnpq.br/
    Abdominal adiposity is a public health challenge that affects public safety personnel exposed to high levels of stress. This complex interaction between psychological and social factors can trigger adverse responses in the body, with a significant impact on quality of life. The main objective of this study was to evaluate abdominal adiposity and investigate its association with food consumption, stress levels, biochemical variables as well as quality of life in public security agents. This is a cross-sectional study carried out with 216 public safety personnel in the state of Espírito Santo. To assess symptoms of stress, food consumption and quality of life, the Stress Symptom Inventory (ISSL), the Food Consumption Frequency Questionnaire (QFCA) and the WHOQOL-bref were used, respectively. Statistical analyzes included chi-square tests, Mann Whitney tests, Poisson regression and multiple regression models (95% CI). There was a prevalence of overweight among public safety personnel (67.8%). It was observed that agents with a higher body mass index (BMI) had an increased prevalence of abdominal adiposity, indicating a significant association between these variables (PR: 3,35 [IC95%: 3,4-5,52; p=0,001]). Furthermore, those with greater adherence to the consumption of ultra-processed foods also showed a higher prevalence of abdominal adiposity(PR: 1,68 [IC95%: 1,51- 2,47] p=0,007. Stress symptoms were associated with a 64% increase in the risk of greater abdominal adiposity, while greater adherence to ultra-processed foods demonstrated a 10% increase in the risk of abdominal adiposity. These results highlight a bidirectional relationship between stress and abdominal adiposity, highlighting the importance of stress and the consumption of ultra processed foods in increasing the risk of abdominal adiposity. Such factors can have metabolic and systemic impacts, resulting in a deterioration in the quality of life of these professionals, highlighting the urgency of interventions in this population
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    Influência de capsinóides sobre o remodelamento e biomarcadores do estresse oxidativo no coração de ratos com obesidade
    (Universidade Federal do Espírito Santo, 2024-07-26) Santos, Késsia Cristina Carvalho; Leopoldo, Ana Paula Lima ; https://orcid.org/; http://lattes.cnpq.br/; Co-orientador2; https://orcid.org/; http://lattes.cnpq.br/; Co-orientador3; https://orcid.org/; http://lattes.cnpq.br/; Co-orientador4; ID do co-orientador4; Lattes do co-orientador4; Leopoldo, André Soares ; https://orcid.org/; http://lattes.cnpq.br/; Orientador2; https://orcid.org/; http://lattes.cnpq.br/; https://orcid.org/; http://lattes.cnpq.br/; Nunes, Karolini Zuqui; https://orcid.org/; http://lattes.cnpq.br/; Camacho, Camila Renata Corrêa; https://orcid.org/; http://lattes.cnpq.br/; 3º membro da banca; https://orcid.org/; http://lattes.cnpq.br/; 4º membro da banca; http://lattes.cnpq.br/; 5º membro da banca; https://orcid.org/; http://lattes.cnpq.br/; 6º membro da banca; https://orcid.org/; http://lattes.cnpq.br/; 7º membro da banca; https://orcid.org/; http://lattes.cnpq.br/
    Obesity increases metabolic complications and induces redox imbalance, favoring oxidative stress in the body. In the cardiovascular system, obesity and oxidative stress reduce metabolic flexibility and cardiac efficiency, as well as causing to cardiac remodeling and dysfunction. In this scenario, capsinoids, present in species of the genus Capsicum, emerge as compounds with potential modulation of obesity and oxidative stress, being able to increase energy metabolism and antioxidant defenses, as well as reduce oxidative damage. Therefore, this study investigated the effects of chronic administration of capsinoids on biomarkers of remodeling and oxidative stress in the hearts of rats with obesity. Initially, male Wistar rats were randomized into standard diet (SD; n = 17) and high-fat diet (HFD; n = 27). The protocol covered 27 weeks divided into: 1) exposure to experimental diets (induction and maintenance of obesity; 19 weeks) and 2) treatment with capsinoids (8 weeks). At week 19, SD and HDF animals were redistributed into: control (C), obese (Ob) and obese with capsinoids (ObCap). During the protocol, food consumption and efficiency, as well as caloric intake were measured. The nutritional profile was monitored by body weight, fat and body adiposity index. The glucose tolerance test, insulin homeostasis indices and lipid profile were used to evaluate comorbidities. Plasma concentrations of insulin, leptin, adiponectin and glucagon were also determined. Cardiac remodeling was measured by the mass of the heart and left ventricle; cardiac damage was verified by measuring plasma troponin I. The biomarkers of cardiac oxidative stress (malondialdehyde - MDA, carbonyl proteins - CBO, advanced protein oxidation products - AOPP and antioxidant capacity - FRAP) and the activity of the enzymes superoxide dismutase and catalase were analyzed. The results indicate that the high-fat diet increased body weight in the HFD group from the 16th week onwards. Obesity increased adipose mass and levels of leptin, cholesterol and insulin. With the exception of cholesterol, treatment with capsinoids did not promote a reduction in these parameters. In the heart, there was an increase in heart and LV mass in the Ob, but without difference after normalization by the tibia length, nor was there any difference with ObCap for these parameters. Regarding troponin I, there was no difference in obesity, however, capsinoids caused a reduction in this marker. Considering oxidative markers, Ob animals presented higher amounts of CBO and AOPP compared to C, however, without effects of capsinoid treatment; ObCap rats also showed higher levels of MDA compared to Ob. Regarding antioxidant activity, Ob and ObCap rats showed increased FRAP, but without differences between groups. In addition, ObCap presented greater activity of antioxidant enzymes. In conclusion, although the obesity model did not cause cardiac remodeling, capsinoids induced a reduction in troponin I and elevation in enzymatic antioxidant activity. However, it caused greater lipid peroxidation in the heart, so in the concentration offered the capsinoids did not constitute a positive strategy for modulation in the oxidative biomarkers
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    Transição de obesidade metabolicamente saudável para obesidade não saudável em adultos do ELSA Brasil : uma análise longitudinal
    (Universidade Federal do Espírito Santo, 2024-07-23) Mendes, Fernanda Duarte; Co-orientador1; https://orcid.org/; http://lattes.cnpq.br/; Co-orientador2; https://orcid.org/; http://lattes.cnpq.br/; Co-orientador3; https://orcid.org/; http://lattes.cnpq.br/; Co-orientador4; ID do co-orientador4; Lattes do co-orientador4; Orientador1; https://orcid.org/; http://lattes.cnpq.br/; Orientador2; https://orcid.org/; http://lattes.cnpq.br/; https://orcid.org/; http://lattes.cnpq.br/; 1º membro da banca; https://orcid.org/; http://lattes.cnpq.br/; 2º membro da banca; https://orcid.org/; http://lattes.cnpq.br/; 3º membro da banca; https://orcid.org/; http://lattes.cnpq.br/; 4º membro da banca; http://lattes.cnpq.br/; 5º membro da banca; https://orcid.org/; http://lattes.cnpq.br/; 6º membro da banca; https://orcid.org/; http://lattes.cnpq.br/; 7º membro da banca; https://orcid.org/; http://lattes.cnpq.br/
    This is a longitudinal study with baseline data (2008/10) and wave 3 (2017/19) from the Longitudinal Study of Adult Health (ELSA-Brasil). The objective is to describe the trajectory of metabolic status in individuals with obesity and the factors associated with the transition to an unhealthy status. Metabolic status was determined using blood pressure, fasting glucose and/or hemoglobin A1c, triglycerides, and HDL cholesterol. Individuals should not have a prior diagnosis of any alterations in these parameters or be taking medication to control them. If any parameter is altered, it is considered metabolically unhealthy obesity (ObMNS); otherwise, it is classified as metabolically healthy obesity (ObMS). Dietary intake was classified according to the degree of food processing, based on the NOVA classification. Physical activity was measured using the International Physical Activity Questionnaire (IPAQ). Sociodemographic variables were collected through a standardized questionnaire, with interviews conducted at each ELSA-Brasil center. For statistical analyses, the Student's t-test and/or Mann-Whitney test were used for continuous variables, and the chi-square or Fisher's exact test for categorical variables. SPSS software version 21.0 was used, with a significance level of 5%. Among the 190 ObMS participants included at baseline, 75.8% transitioned to ObMNS status after an average follow-up of 7.7 years. Alcohol use was considered a risk factor for the transition of metabolic status [RR: 1.359 (95% CI: 1.005 - 1.838)]. Additionally, each 1 cm increase in waist circumference (WC) contributed to a 1% increase in the risk of transitioning from healthy to unhealthy metabolic status [RR: 1.011 (95% CI: 1.004 - 1.018)]. It can be concluded that metabolic health is transient, as most participants transitioned from ObMS to ObMNS. Alcohol consumption was associated with a higher risk of metabolic status deterioration. Furthermore, the accumulation of visceral fat appears to influence the risk of changes in metabolic status. Therefore, it is emphasized that classifying individuals with obesity is important to identify metabolic status and the presence of risk factors for losing a healthy status