Biotecnologia (RENORBIO)

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http://repositorio.ufes.br/handle/10/17563
Programa de Pós-Graduação em Biotecnologia Rede Nordeste de Biotecnologia (Renorbio)

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URL do programa: https://biotecnologia.ufes.br/pt-br/pos-graduacao/RENORBIO

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Navegando Biotecnologia (RENORBIO) por Autor "Arantes, Lidia Maria Rebolho Batista"

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    Fatores determinantes da metilação do gene NR3C1 em usuários do Sistema Único de Saúde no município de Alegre/ES
    (Universidade Federal do Espírito Santo, 2020-04-23) Pinheiro, Júlia de Assis; Freitas, Flávia Vitorino; https://orcid.org/0000-0003-3722-9987; http://lattes.cnpq.br/0564698519017379; Silva, Adriana Madeira Alvares da; https://orcid.org/0000-0002-8078-0304; http://lattes.cnpq.br/6445492335035108; https://orcid.org/; http://lattes.cnpq.br/9785902804240705; Paula, Heberth de; https://orcid.org/0000-0001-6197-4165; http://lattes.cnpq.br/0823599580312700; Errera, Flavia Imbroisi Valle; https://orcid.org/0000-0002-8069-6372; http://lattes.cnpq.br/9337327437538048; Arantes, Lidia Maria Rebolho Batista; https://orcid.org/0000-0001-8230-1218; http://lattes.cnpq.br/2019308149950531; Paula, Flavia de ; https://orcid.org/0000-0001-8679-2982; http://lattes.cnpq.br/7913201450663683
    The NR3C1 gene is related to psychosocial stress and has the promoter region regulated by methylation in the face of environmental exposure. The literature refers to methylation in this gene as related to gestational hunger, war stress and depression. Thus, this study aimed to assess epigenetic methylation changes in the promoter region of the glucocorticoid receptor, in CpGs 40 to 47 in region 1F by pyrosquencing, in SUS users and to correlate with socioeconomic, health, cortisol, vitamin D characteristics. lifestyle and depression. The results revealed a correlation between hypermethylation of NR3C1 region 1F with depression, and hypomethylation with nutritional status, elevated cortisol, use of alcohol and use of psychotropic drugs in the 386 individuals evaluated. The results indicate that the relationship between environment and epigenetics is of great complexity and that the relationship between genotype-environment and the phenotypic outcome may be more refined than previously thought; it depends not only on the stressful event, but also on the type of event, and can result in different clinical consequences. In this sense, the presence or absence of methylation should not be seen only as a risk factor for health or protection, but as a result and result of the individual's interaction with the environment, in the sense of his adaptation to the conditions to which he is exposed