Fatores determinantes da metilação do gene NR3C1 em usuários do Sistema Único de Saúde no município de Alegre/ES
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Data
2020-04-23
Autores
Pinheiro, Júlia de Assis
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Universidade Federal do Espírito Santo
Resumo
The NR3C1 gene is related to psychosocial stress and has the promoter region regulated by methylation in the face of environmental exposure. The literature refers to methylation in this gene as related to gestational hunger, war stress and depression. Thus, this study aimed to assess epigenetic methylation changes in the promoter region of the glucocorticoid receptor, in CpGs 40 to 47 in region 1F by pyrosquencing, in SUS users and to correlate with socioeconomic, health, cortisol, vitamin D characteristics. lifestyle and depression. The results revealed a correlation between hypermethylation of NR3C1 region 1F with depression, and hypomethylation with nutritional status, elevated cortisol, use of alcohol and use of psychotropic drugs in the 386 individuals evaluated. The results indicate that the relationship between environment and epigenetics is of great complexity and that the relationship between genotype-environment and the phenotypic outcome may be more refined than previously thought; it depends not only on the stressful event, but also on the type of event, and can result in different clinical consequences. In this sense, the presence or absence of methylation should not be seen only as a risk factor for health or protection, but as a result and result of the individual's interaction with the environment, in the sense of his adaptation to the conditions to which he is exposed
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Metilação do DNA , Receptor do glicocorticoide , Pirosequenciamento , Sintomas sugestivos de depressão , Estilo de vida , DNA methylation , Glucocorticoid receptor , Pyrosequenching , Symptoms suggestive of depression , Lifestyle , Sistema Único de Saúde , Unified Health System