Ventricular performance and Na+-K+ ATPase activity are reduced early and late after myocardial infarction in rats

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dc.date.accessioned2011-02-10T18:25:52Z
dc.date.available2011-02-10T18:25:52Z
dc.identifier.citationSTEFANON, I. et al. Ventricular performance and Na+-K+ ATPase activity are reduced early and late after myocardial infarction in rats. Braz J Med Biol Res, Ribeirão Preto, v. 42, n. 10, p. 902-911, out. 2009. Disponível em: <http://www.scielo.br/pdf/bjmbr/v42n10/7618.pdf>. Acesso em: 7 fev. 2011.por
dc.identifier.doi10.1590/S0100-879X2009005000015
dc.identifier.issn1678-4510
dc.identifier.urihttp://repositorio.ufes.br/handle/10/592
dc.rightsopen accessen
dc.titleVentricular performance and Na+-K+ ATPase activity are reduced early and late after myocardial infarction in ratspor
dc.typearticleen
dcterms.abstractMyocardial infarction leads to compensatory ventricular remodeling. Disturbances in myocardial contractility depend on the active transport of Ca2+ and Na+, which are regulated by Na+-K+ ATPase. Inappropriate regulation of Na+-K+ ATPase activity leads to excessive loss of K+ and gain of Na+ by the cell. We determined the participation of Na+-K+ ATPase in ventricular performance early and late after myocardial infarction. Wistar rats (8-10 per group) underwent left coronary artery ligation (infarcted, Inf) or sham-operation (Sham). Ventricular performance was measured at 3 and 30 days after surgery using the Langendorff technique. Left ventricular systolic pressure was obtained under different ventricular diastolic pressures and increased extracellular Ca2+ concentrations (Ca2+e) and after low and high ouabain concentrations. The baseline coronary perfusion pressure increased 3 days after myocardial infarction and normalized by 30 days (Sham 3 = 88 ± 6; Inf 3 = 130 ± 9; Inf 30 = 92 ± 7 mmHg; P < 0.05). The inotropic response to Ca2+e and ouabain was reduced at 3 and 30 days after myocardial infarction (Ca2+ = 1.25 mM; Sham 3 = 70 ± 3; Inf 3 = 45 ± 2; Inf 30 = 29 ± 3 mmHg; P < 0.05), while the Frank-Starling mechanism was preserved. At 3 and 30 days after myocardial infarction, ventricular Na+-K+ ATPase activity and contractility were reduced. This Na+-K+ ATPase hypoactivity may modify the Na+, K+ and Ca2+ transport across the sarcolemma resulting in ventricular dysfunction.eng
dcterms.creatorStefanon, Ivanita
dcterms.creatorCade, J. R.
dcterms.creatorFernandes, A. A.
dcterms.creatorRibeiro Junior, Rogerio Faustino
dcterms.creatorTargueta, Gabriel Pelegrineti
dcterms.creatorMill, José Geraldo
dcterms.creatorVassallo, Dalton Valentim
dcterms.issued2009-10
dcterms.languageengen
dcterms.subjectInsuficiência cardíacapor
dcterms.subjectOuabaínapor
dcterms.subjectInfarto do miocárdiopor
dcterms.subjectHeart failureeng
dcterms.subjectOuabaineng
dcterms.subjectMyocardial infarctioneng
dcterms.subjectCalcium handlingeng
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