Efeito Neuroprotetor da Resina de Virola oleifera na Isquemia Cerebral Induzida em Camundongos Hipercolesterolêmicos Knockout para ApoE
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Data
2025-03-17
Autores
Peçanha, Marcos Alves de Souza
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Universidade Federal do Espírito Santo
Resumo
Ischemic stroke (IS) remains a global public health challenge, affecting millions of people and impacting the quality of life of patients and their families. Characterized by complex pathophysiological mechanisms such as cerebral hypoperfusion, excitotoxicity, and oxidative stress, stroke is aggravated by hypercholesterolemia, an important factor that intensifies neuronal lesions and inflammatory processes. Given the limitations of conventional therapies, interest is growing in natural alternatives capable of offering neuroprotection. This study evaluated the neuroprotective potential of Virola oleífera resin, an Amazonian plant rich in phenolic compounds and flavonoids, in ApoE-/- mice with hypercholesterolemia submitted to global cerebral ischemia. The animals were given resin orally (300 mg/kg/day) for seven days before stroke induction. After 48 hours, behavioral, biochemical, and histological evaluations were carried out. The results revealed that treatment with Virola oleifera significantly reduced the area of cerebral infarction, improved motor and cognitive functions, and reduced the amount of necrotic neurons in the affected cortex. In addition, there was a reduction in total cholesterol, LDL, and triglyceride levels, as well as advanced protein oxidation products (AOPPs), a reduction in oxidative stress, and inflammation. These findings suggest that Virola oleifera resin acts in a multifactorial way, protecting the brain against ischemic damage, especially in conditions of metabolic risk. The data obtained reinforces the biotechnological potential of this natural resource as a basis for developing new therapeutic strategies aimed at the prevention and treatment of stroke, encouraging future translational and clinical research.
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Palavras-chave
Acidente vascular cerebral Isquêmico , Virola oleífera , Neuroproteção