Análise histopatológica e econográfica post mortem das tireóides de pacientes infectados pelo vírus da imunodeficiência humana
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Data
2011-08-22
Autores
Fraga, Alana Rocha Puppim
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Editor
Universidade Federal do Espírito Santo
Resumo
The thyroid follicular cells have a close interaction with the immune system and are often injured by several factors determining autoimmune inflammatory response. Immunosuppression caused by Human Immunodeficiency Virus (HIV) infection provides changes in diverse organic systems, including the endocrine system. To assess the consequences of immunosuppression on the thyroid inflammation response, were examined 63 autopsy thyroid glands from patients infected with HIV, of whom 46 were matched by age and gender with patients without HIV infection. In addition to the medical records, representative thyroid gland fragments were analyzed under optic microscope. Also immunohistochemistry for identification of antigens p24, CD4, CD8 and CD20 were performed. Volume measures and glandular ecogenicity were taken correlating with microscopic findings in order to detect pathologic processes. There was no statistical difference in ecogenicity and volume measurements between the groups. The antigen p24 was not identified in any glands. Sixty seven per cent of thyroids sampled, either HIV group or control group, showed inflammatory infiltrate. There was a significant decrease in CD4+ cells in inflammatory infiltrate of HIV group. Microorganisms in thyroid tissue were observed in 19,04% of HIV group and and 3% of control group. CD8+ intraepithelial and interfollicular cells were identified in all glands. CD20+ cells were identified with no significant difference between groups. The inflammatory response may be related, in both groups, of the occurrence of sepsis and thyrotoxic drugs. The reduction of CD4+ cells contributes to changes in the thyroid inflammatory response. The CD8+ intraepithelial cells detected in all glands with little predominance in HIV group may indicate changes in CD4+/CD8+ cells as observed in other organic systems. The measurement of thyroid volume and ecogenicity were not able to identify the specific occurrence of pathological processes between the groups.
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Palavras-chave
Human Immunodeficiency Virus , Thyroid , Inflammation , Immunohistochemistry , Ultrasound , Tireóide , Vírus da Imunodeficiência Humana , Inflamação , Imuno-histoquímica , Ultra-sonografia
Citação
FRAGA, Alana Rocha Puppim. Thyroid ultrasound and histopathological postmortem analysis of HIV infected patients. 2011. 116 f. Dissertação (Mestrado em Doenças Infecciosas) - Programa de Pós-Graduação em Doenças Infecciosas, Universidade Federal do Espírito Santo, Vitória, 2011.