Assistência Farmacêutica em rede
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Programa de Pós-Graduação em Assistência Farmacêutica
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Navegando Assistência Farmacêutica em rede por Autor "Gomes, Rosângela Maria"
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- ItemAvaliação epidemiológica e econômica do tratamento em primeira linha com medicamentos modificadores do curso da doença sintéticos convencionais para artrite psoriásica(Universidade Federal do Espírito Santo, 2022-11-09) Faria, Ronaldo José; Silva, Michael Ruberson Ribeiro da; https://orcid.org/0000000325507249; http://lattes.cnpq.br/2822520981120774; https://orcid.org/0000-0003-0650-128X; http://lattes.cnpq.br/2630619230642585; Ignacchiti, Mariana Drummond Costa; https://orcid.org/0000-0003-3768-949X; http://lattes.cnpq.br/0533640513430050; Gomes, Rosângela Maria; https://orcid.org/0000-0001-8299-4835; http://lattes.cnpq.br/8395018794734460Conventional synthetic disease course modifying drugs are the first-line treatment to inhibit the progression of psoriatic arthritis. Despite their wide clinical use, few studies have been conducted to compare these drugs for the treatment of psoriatic arthritis. In this regard, an observational study was conducted to identify the profile of use and expenditures with these drugs in a real-life setting. A longitudinal study was conducted from a national centralized patient database in Brazil. Patients with psoriatic arthritis who obtained their first synthetic disease-modifying drug through SUS were included. The market share of the drugs, persistence in treatment, drug costs, and cost per response, considered as the cost per persistent patient were evaluated. Results: a total of 1,999 individuals with psoriatic arthritis were included. Methotrexate was the most commonly used drug (44.4%), followed by leflunomide (40.6%), cyclosporine (8.2%), and sulfasalazine (6.8%). Methotrexate and leflunomide had a higher market share compared to cyclosporine and sulfasalazine over the years. Treatment persistence was highest for leflunomide (58.9% and 28.2%), followed by methotrexate (51.6% and 25.4%) at six and 12 months, respectively. Leflunomide was found to be the most expensive drug, with an average annual cost of R$ 749.67, followed by sulfasalazine (R$ 251.58), cyclosporine (R$ 230.73), and methotrexate (R$ 95.06). Methotrexate was the drug with the lowest cost per response. Methotrexate had the best cost-perresponse ratio due to its lower cost and a slightly lower proportion of persistent patients when compared with leflunomide, which supports its current use as a first drug indicated in the treatment of psoriatic arthritis. Leflunomide showed greater treatment persistence, however, it was the most expensive drug.
- ItemEstudo de utilização de medicamentos em indivíduos residentes no município de Alegre-ES: achados e implicações(Universidade Federal do Espírito Santo, 2022-12-21) Bazoni, Patrícia Silva; Silva, Michael Ruberson Ribeiro da; https://orcid.org/0000000325507249; http://lattes.cnpq.br/2822520981120774; https://orcid.org/0000-0002-3829-4900; http://lattes.cnpq.br/6643287346058686; Meira, Eduardo Frizzera; https://orcid.org/0000-0002-0210-4319; http://lattes.cnpq.br/9651828257315064; Gomes, Rosângela Maria; https://orcid.org/0000-0001-8299-4835; http://lattes.cnpq.br/8395018794734460The use of drugs as a therapeutic resource has evolved a lot throughout human history, becoming the main technological instrument in the field of health. In addition, they can provide several benefits to the user's health, however, when used incorrectly and unnecessarily, they can trigger several damages to the patient's health. In this context, the objective of this study was to analyze the profile of medication use, prevalence and factors associated with the occurrence of polypharmacy and self-medication in the population of Alegre, Espírito Santo. An epidemiological study with a cross-sectional design was carried out, using a household survey, in the city of Alegre, between November and December 2021. A descriptive analysis of sociodemographic and clinical characteristics was carried out, as well as the prevalence of polypharmacy and self-medication. of the interviewees. In this study, the occurrence of minor polypharmacy was defined as the use of two to four medications and major polypharmacy as the use of five or more medications. The occurrence of selfmedication was defined as the use of medication on one's own to treat self-recognized health problems. Factors associated with self-medication were assessed using Poisson regression and factors associated with minor and major polypharmacy using logistic regression. The prevalence of minor polypharmacy was 44.9% and of major polypharmacy was 20.2%. Additionally, it was found that 69.4% of respondents practiced self-medication. Factors associated with lower polypharmacy were: older age group, female gender, self-declared white, worse quality of life, medical appointments in the last year, use of the Municipal Basic Pharmacy and presence of comorbidities. On the other hand, the factors associated with major polypharmacy were the same as minor polypharmacy, with the exception of the gender variable and having only one disease when compared with patients who had two or more diseases. In addition, higher income, fair and poor/very poor self-perception of health, not self-medicating, problems with adherence to treatment and not using medicinal plants were factors associated with the occurrence of higher polypharmacy. The factors associated with the occurrence of self-medication were younger age, female sex, consumption of alcoholic beverages, problems with adherence to pharmacotherapy and, as a protective factor, being in greater polypharmacy. The results of this study can contribute to the optimization of patient care, reinforce the need for health education actions and the search for the rational use of medicines, as well as provide subsidies for public policies to promote health.
- ItemQualidade de vida relacionada à saúde e fatores associados em um município de pequeno porte durante a pandemia de COVID-19(Universidade Federal do Espírito Santo, 2023-08-16) Pezzin, Josiane; Silva, Michael Ruberson Ribeiro da; https://orcid.org/0000000325507249; http://lattes.cnpq.br/2822520981120774; https://orcid.org/0009-0009-8339-0561; http://lattes.cnpq.br/9172067654108376; Bortoli, Valquíria Camin de; https://orcid.org/0000-0001-5801-8447; http://lattes.cnpq.br/3992098322056730; Gomes, Rosângela Maria; https://orcid.org/0000-0001-8299-4835; http://lattes.cnpq.br/8395018794734460Quality of Life (QL) is about the individual's perception of their position in life in the context of the culture and value systems in which they live and in relation to their goals, expectations, standards and concerns. For healthcare applications, the term HealthRelated Quality of Life (HRQoL) is often used. Research in this area is of great relevance to aid in the development of public policies, evaluation of outcomes in clinical trials and economic analysis. However, population-based research on HRQoL, conducted in different sociocultural settings, is scarce. In this sense, this work aimed to evaluate HRQoL and its associated factors in a small brazilian municipality during the period of the COVID-19 pandemic. This is an epidemiological, cross-sectional, population-based study carried out through a household survey, during the period from november to december 2021 in the city of Alegre/ES, Brazil. The sample was representative of the city's urban population and consisted of individuals aged ≥ 18 years. Through face-to-face interviews, self-reported sociodemographic data, life habits, health-related characteristics, comorbidities and an assessment of HRQoL were collected using the EQ-5D-3L instrument. Data were submitted to statistical analysis and presented in the form of graphs and tables. The association between HRQoL levels and the explanatory variables collected using the Tobit regression model was tested. The study was approved by the UFES Research Ethics Committee under Opinion nº 3,428,060. 694 individuals were interviewed, predominantly female (72.9%) and mean age was 53 years (SD = 18.9). The most prevalent comorbidities were high blood pressure and anxiety. In the analysis of the EQ-5D, 43.23% of the interviewees reported the absence of problems in all dimensions. The dimension with the highest frequency of problems was pain/discomfort, followed by anxiety/depression. The mean HRQoL value obtained was 0.818 (SD = 0.195) on the EQ-5D descriptive system and 77.8 (SD = 18.9) on the EQ-VAS visual analogue scale. The correlation between these values was positive and moderate. The factors that maintained an association with HRQoL in the final Tobit regression model (p ≤ 0.05) were: self-perceived health, disability, polypharmacy, hospitalization in the last year, anxiety, rheumatoid arthritis, obesity and medication adherence problems. In general, the influence of these factors on HRQoL is already well discussed in the literature, except for problems with medication adherence. Along with polypharmacy, this factor highlights the importance of strengthening pharmaceutical care services and multidisciplinary teams in health care in Alegre/ES. The profile of reporting problems in the dimensions of the EQ-5D3L is consistent with that found in national and international studies. The results of this study present a health assessment of a small municipality, useful for local health managers, and which enriches the literature in the area with data on HRQoL in settings and contexts that have been little studied.