Ciências Farmacêuticas

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Navegando Ciências Farmacêuticas por Autor "Andrade, Tadeu Uggere de"

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    Estudo de utilização de medicamentos em pacientes com doença de Parkinson
    (Universidade Federal do Espírito Santo, 2019-02-22) Colatto, Luana Laura; Ayres, Lorena Rocha; Guimarães do Bem, Daniela Amorim Melgaço; Baldoni, André de Oliveira; Andrade, Tadeu Uggere de
    Aging is leading to an increasing incidence of chronic degenerative illnesses such as Parkinson’s disease. In addition, the elderly population is characterized by the concomitant presence of one or more chronic conditions that bring with it the challenge of polypharmacy, and with it the complexity of therapeutic regimens. Potentially inappropriate medications, which can cause severe adverse effects when given to the elderly, may interfere with the success of pharmacotherapy in these patients. Together with all these factors, depression and sociodemographic characteristics may influence adherence to pharmacological treatment. In this context, we identified the prevalence in the use of potentially inappropriate medications, according to the Beers criteria 2015 and, also, we evaluated the adherence to the drug treatment, both in patients with Parkinson’s disease. It is a cross-sectional study, developed in patients diagnosed with Parkinson’s disease and who are part of the Chronic Management Program of Unimed-Vitória. We evaluated the older adults with 60 years or more included in the digital Healthmap® platform in the year 2017. Data were collected using questionnaires (structured interview questionnaire, Hoehn and Yahr Scale, Morisky-Green Test, Brief Medication Questionnaire, MedTake) and through the digital Healthmap® platform. The association between the use of potentially inappropriate medications and the independent variables was analyzed by univariate logistic regression with their respective confidence intervals of 95%. For the multiple model, the variables that presented p < 0.20 were selected. The association between adherence and the independent variables was analyzed using Fisher's exact test. The prevalence of 83.3% was verified in the use of potentially inappropriate medications. In the multiple logistic regression model, the associated variables to use were female (p = 0.03), receive seven or more home visits (p = 0.03), some anatomical therapeutic chemical classification – code M: musculo-skeletal system (p = 0.04) and code A: alimentary tract and metabolism (p = 0.005), and the use of psychotropic medication (p = 0.03). Consulting with four or more different medical specialties was considered as a protection factor for the use of potentially inappropriate medications. The results found in the assessment of adherence ranged from 0.0% to 76.1%, considering total adherence to the prescribed treatment, according to the score of each questionnaire. There were no significant associations between the variables and adherence to treatment. This study demonstrated a high prevalence of potentially inappropriate medications in this population, evidencing the need to disseminate this criteria and the adoption of tools that promote the rational use of drugs and, on the other hand, a low therapeutic adherence of the patients, which corroborates the need for a multidisciplinary approach, particularly with the participation of a pharmacist, to develop strategies to facilitate understanding of the pharmacological treatment of patients with Parkinson’s disease.
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    Intoxicação aguda com clorpirifós tem impacto distinto na sobrevida e função cardiorrespiratória de ratos hipertensos e normotensos
    (Universidade Federal do Espírito Santo, 2023-02-27) Aitken, Andrew Vieira; Nazaré Souza Bissoli; https://orcid.org/0000-0002-3456-2437; http://lattes.cnpq.br/8865368585732583; Sampaio, Karla Nivea; https://orcid.org/0000000302930482; http://lattes.cnpq.br/5951704470576361; https://orcid.org/0000-0001-9229-9369; http://lattes.cnpq.br/4245028618458609; Andrade, Tadeu Uggere de; https://orcid.org/0000-0001-6387-7895; http://lattes.cnpq.br/4947627030102292; Junior, Antonio Ferreira de Melo; https://orcid.org/0000-0001-6831-1823; http://lattes.cnpq.br/1448209037754167
    Hypertension is the most important and well-known risk factor for development of cardiovascular disease (CVD). Additionally, other factors such as acute organophosphate (OP) poisoning have been pointed as a CVD risk factor. However, no studies have compared the cardiorespiratory effects induced by intoxication with OP in hypertensive and normotensive situations. Therefore, our study aimed to evaluate and compare acute toxicity and cardiorespiratory effects induced by the OP, chlorpyrifos (CPF), in normotensive and hypertensive rats. In order to study this, adult, male, Wistar and Spontaneously Hypertensive rats (SHR) were injected, intraperitoneally (i.p.) with saline or with CPF at the doses of 10, 20 and 30 mg/kg and evaluated for acute toxicity and lethality and 48 hours after testing, brainstem samples were collected for assays of oxidative stress and inflammation. Independent groups of animals were submitted to catheterization of femoral vein and artery under anesthesia with ketamine/xylazine (70/10 mg.kg-1 , i.p.) and 24 hours after rats were injected with saline or CPF (20mg/kg). 24 hours after the injections, baseline cardiorespiratory parameters were recorded and the Bezold-Jarisch Reflex (BJR), chemoreflex and cardiac autonomic tone were evaluated. After this, brainstem and blood samples were obtained for quantification of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activity. For data analysis we used generalized estimating equations (GEE), three-way ANOVA for repeated measures and two-way ANOVA, followed by Bonferroni and Tukey post-hoc, when necessary. Hypertensive rats presented more intense acute toxicity signs following CPF intoxication and 8,34% lethality in non operated animals and 33% in animals previously submitted to catheterization. Intoxication with CPF attenuated baseline ventilation in SHR, impaired the hypotensive and bradycardic responses of BJR in Wistar and attenuated tachypneic response of chemoreflex in both strains. CPF promoted inhibition of AChE and BuChE enzyme activities, increased levels of advanced oxidative protein products, nitrite, nitrate, as well as elevated expression of tumor necrosis factor (TNF) and angiotensin-1 converting enzyme in Wistar rats, without evoking changes in SHR. Our findings show that SHR presented increased susceptibility to acute toxicity and lethality to CPF, in doses that were sublethal to normotensive animals. We also show that cardiorespiratory reflexes were differentially impacted by intoxication with CPF in hypertensive and normotensive rats and that cardiorespiratory disfunction seems to be associated with interference of cholinergic transmission, oxidative stress, and inflammation. These findings suggest an increased susceptibility to acute toxicity in hypertension, which could indicate a significant risk to vulnerable populations