Ciências Fisiológicas

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http://repositorio.ufes.br/handle/10/17570
Programa de Pós-Graduação em Ciências Fisiológicas

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Telefone: (27) 3335 7340
URL do programa: http://www.cienciasfisiologicas.ufes.br/pt-br/pos-graduacao/PPGCF

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Navegando Ciências Fisiológicas por Autor "Alvim, Rafael de Oliveira"

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    Efeitos da restrição do fluxo sanguíneo associada ao exercício de força sobre o dano muscular esquelético e o sistema cardiovascular
    (Universidade Federal do Espírito Santo, 2018-04-23) Curty, Victor Magalhães; Vasquez, Elisardo Corral; Barauna, Valério Garrone; Mill, José Geraldo; Sousa, Nuno Manoel Frade de; Alvim, Rafael de Oliveira; Leite, Richard Diego
    Muscle damage is considered as one of the main mediators of the musculoskeletal adaptations provided by strength exercise (SE). However, it is hypothesized that low intensity PE (20-50% of 1RM) associated with restriction of blood flow (RFS) can provide similar adaptations regardless of whether or not muscle damage occurs. This study aimed to evaluate the effects of RFS associated with different protocols of strength exercise on skeletal muscle damage and cardiovascular system. Three different experimental protocols were evaluated: 1º) High-intensity eccentric strength exercise (HIEC, 130% of 1RM), in which the participants performed 3 sets of 10 maximal repetitions, in two conditions (with or without the BFR); 2º) Low-intensity strength exercise (LISE, 40% of 1RM), in which the participants performed 3 sets until muscle fatigue, also under conditions with or without the BFR; and lastly, 3º) Lowintensity strength exercise (LISE, 40% of 1RM), performed again 3 sets until muscular fatigue under different percentages of BFR (0, 40, 60 and 80%). Of the experimental protocol 1, we observed that the range of motion (ROM) decreased similarly in both exercise conditions immediately after exercise. However, only HIEC presented ROM reduced at the 24-hour post-exercise.
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    Efeitos de doses controladas do suplemento OxyElite Pro sobre a perfomance física em ratos Wistar
    (Universidade Federal do Espírito Santo, 2017-04-26) Zovico, Paulo Vinicios Camuzi; Baraúna, Valério Garrone; Sousa, Nuno Manuel Frade de; Alvim, Rafael de Oliveira; Rodrigues, Lívia Carla de Melo
    OxyElite Pro (OEP) is a dietary supplement to increase metabolism which contains as key stimulant the ingredient 1,3-dimethylamylamine (DMAA). Serious adverse effects have been reported after OEP consumption. However, these effects are related to unknown doses or overdose of supplement. Thus, the aim of this study was to evaluate acute and chronic OEP affects, at controlled doses in Wistar rats, on physical performance, hemodynamic responses, spontaneous locomotor activity, behavioral parameters and metabolic parameters, liver injury markers and oxidative stress markers, and mitochondrial biogenesis in skeletal muscle. For this we use the following groups of rats: control, 4,3 mg OEP/kg (minimum dose), 12,9 mg OEP/kg (maximum dose) and 25,8 mg OEP/kg (not recommended). All groups were submitted to supplementation with OEP for 4 weeks and the experimental protocols were performed 30 min after the first OEP administration (acute response) and 30 min after the last OEP administration at the end of the forth week (chronic response). Running distance and running time increased after acute administration of 12,9 mg OEP/kg (2.6-fold) and 25,8 mg OEP/kg (2,8-fold). Since no effect on the exercise tolerance test was observed at the lower OEP dose (4,3 mg OEP/kg), this group was removed from further analyzes. Acute supplementation with 12,9 mg/kg OEP was able to increase HR without significantly affecting blood pressure (BP), however, non-recommended doses (25,8 mg/kg OEP) showed an increase in BP and HR. On other hand, running distance and running time decreased after daily supplementation for 4 weeks also in both groups (64% in 12,9 mg OEP/kg and 72% in 25,8 mg OEP/kg). Chronic supplementation at both 12,9 and 25,8 mg OEP/kg decreased TBARS levels in soleus muscle (36 and 31%) and liver (43 and 25%). AOPP was also decreased by both doses in the liver (39 and 45%). Chronic administration of the highest dose, 25,8 mg OEP/kg, was able to reduce mRNA expression of PGC-1α in soleus muscle (25%). No effect was found in other variables such as spontaneous physical activity, behavioral parameters, body weight, food and water intake, hepatic toxicity, cardiac oxidative stress and mitochondrial DNA amount. Concluded that maximum and not recommended doses of OEP ingested acutely presented stimulating effect on the ability to exercise. Doses not recommended with OEP significantly increase hemodynamic responses. However, its daily consumption for 4 weeks showed antioxidant effects in soleus muscle and liver which may have decreased the PGC-1α mRNA expression on soleus muscle and contributed to the impaired performance in the exercise tolerance test.